Context:The distribution of various subtypes of lymphomas in India is different from other parts of the world. There is scarce multicentric data on the pattern and outcomes of lymphomas in India.Aims:The aim of this study is to evaluate the histopathological and the clinical pattern and treatment outcomes of lymphomas in India based on the retrospective data collected from a multicenter registry.Materials and Methods:Retrospective data was collected at 13 public and private hospitals in India for patients diagnosed with lymphoma between January 2005 and December 2009. The data collection was performed in the setting of a multicenter lymphoma registry Survival analyses were performed using the Kaplan-Meier method and compared using the log-rank test.Results:Non-Hodgkin's lymphoma (NHL) constituted 83.17% and Hodgkin's lymphoma (HL) for 16.83% of the 1733 registered and analyzed cases. Diffuse large B cell lymphoma (DLBCL) was the most common NHL (55%) followed by follicular lymphoma (11%). CHOP was the most common chemotherapy regimen administered (84%) while rituximab was used in 42.7% of those with DLBCL. Survival analysis of treatment naïve DLBCL patients (n = 791) was performed. Of these, 29% were lost to follow-up, 20% with active disease. The median follow-up in surviving patients is 31 (range: 1-88) months. Median progression-free survival (PFS) and overall survival (OS) in DLBCL patients has not reached. There was no significant difference in median PFS (69 months vs. 61 months, P = 0.1341), but OS was significant not reached (NR) vs. NR, P = 0.0012) within international prognostic index high or intermediate subgroups. Rituximab use was associated with significantly prolonged PFS (NR vs. 82 months, P = 0.0123), but not OS (NR vs. NR, P = 0.2214). Cox regression analysis in treatment naïve DLBCL patients showed a performatnce status, stage and receipt of six or more cycles of chemotherapy to be significantly associated with OS and all of the preceding plus rituximab use significantly associated with PFS.Conclusions:Our analysis confirms previous reports of distribution of lymphoma subtypes in India and suggests that patients who are able to receive the full course of chemotherapy achieve a better outcome. This indicates the importance of ensuring compliance to treatment utilizing various measures including patient and family counseling. Prospective studies are required to confirm these findings.

Background: Several studies have shown that people who have been exposed to radiation or to asbestos, benzene, pesticides, and other chemicals used in rubber manufacturing may be at higher risk for developing multiple myeloma (MM). Those exposed to wood products, such as carpenters, furniture makers, and paper makers, are also at higher risk of developing this disease. Most occupational cohort studies lack statistical power for rare outcomes such as MM and many case-control studies suffer from small numbers of exposed subjects in specific occupation, job title or chemical exposure categories. This study aimed to investigate the distribution of MM among different occupational groups. Methods: A total of 100 cases were studied in the out patient department (OPD) of the Clinical Haematology Department, Gauhati Medical College and Hospital, and Guwahati, Assam, India. It was a hospital based crosssectional descriptive study. The proforma was prepared based on universal standard protocols for evaluation of MM which contains separate history, examination and investigation parts. The International Myeloma Working Group (IMWK) criteria for classification of monoclonal gammopathy, multiple myeloma and related disorders were used for diagnosis of the disease. Data were analyzed using statistical package and results and observations were presented in tabular form. Statistical tests were applied wherever required. Results: Statistical analysis suggested that farmers and housewives were more vulnerable to MM and the prevalence was significantly high (p>0.00001) among farmers followed by housewives; prevalence of MM was significantly high (p>0.00001) among the farmers working in agriculture as compared to those in farms; there was some difference (p<0.00001) in relation to risk of pesticide exposure between cultivation of crops and vegetable. Pesticide exposure was relatively high with cultivation of crops than vegetable; among the farmers working in farms, those who work in farm with furred animals are more vulnerable (p<0.00001) to the prevalence of MM than the others; frequency of pesticide exposure had no effect (p=0.354) on the prevalence of MM; prevalence of MM was significantly high (p=0.0005) among farmers who expose to pesticides for more than 5 years as compared to those exposing for less time and prevalence of multiple myeloma is very insignificant (p<0.00001) among the fruit and pesticide sellers. Conclusions: Prevalence of MM was significantly high (p=0.0005) among farmers who expose to pesticides for more than 5 years and carpenters who worked for more than 4 years.

Introduction: Multiple Myeloma (MM) is a clonal plasma cell neoplasm characterized by the proliferation of plasma cells, monoclonal protein, Osteolytic bone lesions, renal disease and immunodeficiency. It accounts for 15% of lymphatohematopoietic cancers (LHC) and 2% of all cancers in the US. Objectives: To see distribution of serum creatinine, calcium and protein level among MM cases. Methods: A hospital based cross-sectional descriptive study was conducted in the OPD of the

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