INTRODUCTION Multiple myeloma is the second most common haematological malignancy in the United States. Recently, it has been reported that globally approximately 0.8 percent of all cancer cases and 0.9 percent of all cancer deaths are attributed to multiple myeloma (MM) and more than 114,000 new cases were diagnosed in 2012 (0.8 percent of total cancer cases). The last decade has seen major advances in understanding the aetiology, biology of multiple myeloma and advances in therapy have improved survival for patients with myeloma making it prototype for the paradigm of transforming into a chronic illness. This study describes epidemiology, pathology, clinical features, diagnosis and prognosis of multiple myeloma. As an increasing body of literature points to an interplay between the MM and its probable risk factors, pathology, diagnosis and prognosis.
Compression of cranial nerves (CNs) by an intracranial plasmacytoma is considered to be an unusual presentation of multiple myeloma (MM). Here, we report a case of right 3 rd cranial nerve involvement as an initial presentation, which emphasizes the fact that third CN palsy can be the first presenting feature of Multiple Myeloma (MM).
We report an 25-year-old young male patient who presented with sudden onset multiple generalized skin lesions of dusky erythematous plaques of various size and shape all over the body which tends to bleed on rubbing. Histological evaluation revealed leukemia cutis with underlying atypical infiltrate contained atypical myeloid forms consistent with acute myelogenous leukemia (AML). His skin biopsy provided the first evidence of progression to AML. AML presenting with sudden onset leukemia cutis in a young boy is an extremely rare entity.
We report a case of a 54-year-old female with history of multiple myeloma on remission with botizomib-dexamethasone regien treatment presents with enlargement and coming out of her right eye with pain, swelling, tearing and pain in the backbone. On examination, it was found that she has proptosis, chemosis, and diplopia along with marked diminision of vision. Initial workup and treatment did not yield significant results; eventually she was found to have myelomatous changes in her right orbit on CT scan & magnetic resonance imaging (MRI) of orbit and was diagnosed with multiple myeloma of the orbit that resolved some amount with radiation. This case tends to highlight the importance of considering myeloma of the orbit in a multiple myeloma patient who is on remission with chemotherapy.
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