Aorto-iliac Occlusion-7ohnstone et al.- MEDICAL JOURNAL 977 no part in the genesis of this lactate, and infusion of A.C.D. bank blood had been stopped previously.The quantities of lactate and pyruvate circulating during the immediate post-operative period amount to 4 mEq/l. at maximum. No significant change occurs in hydrogen-ion concentrations as a result of these metabolites, and although the reason for their continued production is at present obscure they do not appear to be harmful per se.
SummarySix cases have been studied during reconstructive surgery for aorto-iliac disease. Infrarenal aortic occlusion produces severe desaturation of blood in the lower limb, leading to anaerobic production of lactate. The change in hydrogen-ion concentration produced is small, transient, and not significant at normothermia.Alterations in hydrogen-ion concentration due to release of anoxic metabolites does not appear to be the cause of systemic hypotension after release of aortic clamps.
When lichen planus strikes families, a very rare happening, it is likely to afflict younger members, to erupt more acutely, extensively, and gravely, attacking also nails and mucous membranes, and to recur. Ten patients with familial lichen planus, two each from five distinct Caucasian families, the parents of whom were unrelated by birth, were found to be carrying HLA-B7 statistically more frequently than in the normal population or in those with the characteristic forms of lichen planus. We hint that their genotype might have rendered them susceptible to a pathogen that precipitated their disease.
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