A novel, rapid, precise and accurate stability indicating RP-HPLC method was developed and validated for the simultaneous estimation of Ibuprofen and Carisoprodol in combined pharmaceutical formulation. Chromatographic separation was achieved on Kromasil C18 column (250×4.6mm, 5μm) with UV detection at 260nm. The mobile phase consisting of 0.1% Ortho Phosphoric Acid (OPA) and acetonitrile in a ratio of 40:60v/v and adjusted the fl ow of mobile phase to 1.0mL/min. The method was showing linear response in the concentration range over 100-600μg/mL for Ibuprofen and 43.75-262.5μg/mL for Carisoprodol. The peaks for Ibuprofen and Carisoprodol were detected 2.256 min and 3.141 min respectively. The mean percentage recoveries of Ibuprofen and Carisoprodol were found to be 99% and 99.18% respectively. The method was validated and was successfully employed for the routine quantitative analysis of pharmaceutical formulations containing Ibuprofen and Carisoprodol in combined tablet dosage form.
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