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Primary hyperparathyroidism (PHPT) has a variable clinical expression. Majority of the patients are asymptomatic. Symptomatic PHPT with classical skeletal, renal, abdominal and neuro-psychiatric manifestations have become exceedingly rare. Asymptomatic maternal PHPT manifesting as neonatal hypocalcaemic convulsions is another rare entity. The commonest cause of PHPT are solitary parathyroid adenomas. These benign tumors are extremely small being difficult to identify even at surgical exploration. Very large tumors known as giant adenomas are uncommon. Double parathyroid adenomas account for only a small percentage of the lesions associated with PHPT. Considerable debate exists as to whether double adenomas are a distinct entity or represent early stages of four gland hyperplasia. We report two interesting cases of PHPT with classical features, that have become rare today such as nephrolithiasis, nephrocalcinosis, and X-ray findings of bone disease, caused by unusual pathological lesions like double and giant adenomas and discuss rare presentations like neonatal convulsions.

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Background Recently, statins have been associated with improved survival in certain cancers. The aim of this study was to evaluate the impact of statins on the outcome of patients undergoing surgery for pancreatic cancer. In addition, the effect of statins on the histopathological characteristics of the disease was assessed. Methods A retrospective review of the prospectively maintained hepato‐pancreatico‐biliary database was performed and patients with pancreatic cancer who underwent surgery between January 2014 and December 2017 were included. Statistical analysis was performed to assess the impact of statins on histopathological characteristics and survival outcome. Results A total of 151 patients were included, of whom 71 underwent pancreatic resections and 80 underwent trial dissection and bypass procedures. In the operated group, 20 patients were on statin therapy preoperatively. With respect to disease‐free survival, tumour size (P = 0.023) and lymphatic invasion (P = 0.015) were significant variables on univariate analysis. Gender (P = 0.022), adjuvant chemotherapy (P < 0.001), lymphatic invasion (P = 0.021) and tumour size (P = 0.041) were significant variables on univariate analysis with respect to overall survival. Multivariate analysis identified adjuvant chemotherapy as the only independent predictor of overall survival (P < 0.001). No correlations between the use of statins and the histopathological characteristics were identified. Conclusion Adjuvant chemotherapy is an independent predictor of overall survival in patients undergoing surgery for pancreatic cancer. Statin therapy does not influence survival outcomes and histopathological characteristics following surgery for pancreatic cancer.