The aim of the present work is to formulate and evaluate Desloratadine Sugar free oral liquid dosage form. Desloratadine is an anti-histamine drug which is used to treat allergic reactions such as chronic utricaria, watery eyes and runny nose. In this Present work Desloratadine sugar free oral liquid dosage form was formulated by using artificial sweeteners with the help of simple mixing technique and subjected to various evaluation tests. The Pre-formulation studies like identification of pure drug by melting point method, solubility, Drug-Excipients compatibility studies by FTIR studies were evaluated. Post formulation studies like oranganoleptic properties, Physico-chemical properties, Assay, Related substances and Microbial examination were evaluated. Organoleptic property has shown that the all formulations was found to be clear orange and complies with innovator. Assay of Desloratadine and sodium benzoate of all six formulations F1, F2, F3, F4, F5, and F6 were determined and found to be 99.1%, 99.8%, 100.1%, 100.2%, 100.1% and 99.9% respectively. Related substances of all the formulations were determined and the impurities A and B were found to be within the limits and there is no any unspecified impurity. Microbial examinations of all the formulations are determined and the total bacterial count and fungal count are within the limits and E.coli is absent. The formulation of Desloratadine sugar free oral liquid dosage form by using artificial sweeteners was Developed and evaluated.
Though there was not enough data available throughout the phytosome research, authors tried maximum to provide all inputs for the preparation of phytosomes. The objectives of the present research work focused on the investigation of phyto chemical constituents of aqueous extract, preparation of nanophytosomes of aqueous extract. Momorica charantia plants were collected locally from the village of Muhavur. The leaves were separated from the plant and the leaves were washed with water and then again washed with chloroform to remove soil particles and the leaves were spread and dried in the shade for 4 days. The aqueous extract of Momorica charantia obtained was subjected to qualitative analysis to test the presence of various phytochemicals. Particle size of prepared nanophytosomes was analyzed by photon correlation spectroscopy using a Shimadzu particle size analyzer (SALD 2101, Japan). Diluted nanophytosomal suspension was placed into the sample dispersion unit while stirring at room temperature (in order to reduce the inter particle aggregation). All analyses has been performed in triplicate. Nanophytosomes of Momordica charantia aqueous extract was effectively prepared and tested. The aqueous extract was evaluated phyto chemical screening followed by all characterization studies. Phytochemical screening study remaining that the extract consists of flavanoids. The characterization study showed that the phytosomes are having nano size, good stability properties with round to spherical shape with smooth surfaces.
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