Objective: The aim of the present work was to formulate and evaluate oral disintegrating tablets of Ketorolac tromethamine HCl by statistical experimental design. The Ketorolac is an NSAIDs drug, which has high solubility and high permeability (BCS class I). Methods: Tablets were prepared by direct compression technique using dehydrated Banana powder (Musa acuminata) and Plantago ovata powder (Ispaghula) as independent variables. In vitro disintegration time and % drug release were selected as dependent variables. The model was found to be linear and the curvature effect was significant. Therefore, study resorted to composite design for optimization. Results: DSC studies indicated that the drug and excipients were compatible. Pre-compression parameters had shown fairly good flow properties. The directly compressed tablets were evaluated for pharmaco technical properties and were found to be within specified limits. Kinetic studies revealed that drug release from all formulations followed first order release. Based on simulation given by the software most economical batch which was in desired range was selected. Conclusion: The statistical model is mathematically valid as the experimental values and predicted values suggested by the model were relatively close to each other. The results demonstrated the effectiveness of the proposed design for development of Ketorolac tromethamine HCl fast disintegrating tablets with optimized properties.
Though there was not enough data available throughout the phytosome research, authors tried maximum to provide all inputs for the preparation of phytosomes. The objectives of the present research work focused on the investigation of phyto chemical constituents of aqueous extract, preparation of nanophytosomes of aqueous extract. Momorica charantia plants were collected locally from the village of Muhavur. The leaves were separated from the plant and the leaves were washed with water and then again washed with chloroform to remove soil particles and the leaves were spread and dried in the shade for 4 days. The aqueous extract of Momorica charantia obtained was subjected to qualitative analysis to test the presence of various phytochemicals. Particle size of prepared nanophytosomes was analyzed by photon correlation spectroscopy using a Shimadzu particle size analyzer (SALD 2101, Japan). Diluted nanophytosomal suspension was placed into the sample dispersion unit while stirring at room temperature (in order to reduce the inter particle aggregation). All analyses has been performed in triplicate. Nanophytosomes of Momordica charantia aqueous extract was effectively prepared and tested. The aqueous extract was evaluated phyto chemical screening followed by all characterization studies. Phytochemical screening study remaining that the extract consists of flavanoids. The characterization study showed that the phytosomes are having nano size, good stability properties with round to spherical shape with smooth surfaces.
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