3,3′-Azothiophenes demonstrate effective photo-induced isomerization in solution. Activation energies and entropies confirm the thermal stability of cis conformations at 20 °C.

The synthesis, resolution, and pharmacological evaluation of the 2-thienyl analogues of ephedrine and $-ephedrine are described, and assignments of their absolute configurations are made.DRUGS which contain benzene rings and their thiophen analogues show similar pharmacological activities1 Although many thienylalkylamines have been investigated the thiophen analogues of ephedrine [(I) ; (-)-isomer shown] and +-ephedrine [( 11) ; (+)-' isomer shown] have not been reported. We have synthesised erythoand threo-2-methylamino-l-(2-thienyl)propan-

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