Aims: To compare the effectiveness and tolerability of soft gelatine capsule versus Extended-release tablet containing clindamycin with clotrimazole in vaginal infections. Subjects and Methods: Following baseline vaginal examination, 66 women having clinical diagnosis of vaginal infection were randomized to receive three doses [once daily] of an immediate release (SG-group) or an extended release combination of clindamycin with clotrimazole (ER-group) and followed up for assessing resolution of clinical and microbiological evidence of vaginal infection by 8 th day; maintenance of clinical and microbiological cure at 29 th day; and occurrence of side effects. Results were presented using descriptive statistics. Qualitative data was analyzed by Fischer's Exact test Unpaired t-test was used for quantitative data. Results: 27 women from SG-group and 30 women from ER-group completed the study. In SG-group, 69.23% had complete cure and 7.69% had partial remission at 8 th day of which 88.89% maintained remission, while in ER-group 73.68% women had a complete cure of which 85.71% maintained remission on 29 th day. Delayed remission was observed in 25% women from SG-group and 60% women from ER-group, while none of the women experienced intolerable adverse effects. Conclusion: Both formulations containing clindamycin plus clotrimazole were effective, as empiric therapy, in inducing and maintaining microbiological as well as clinical remission in women with clinical diagnosis of vaginal infection to a similar extent but should not to be recommended for cases specifically identified to have trichomoniasis. An adequately powered study using a larger population should be conducted to further explore differences between these two formulations.
Background/Aim: Alcohol remains one of most common cause of liver disease in India, hence the present study was undertaken to assess the clinical profile and treatment chart review of alcoholic liver disease (ALD) patients. Materials and Methods: Hospital based prospective and observational study was carried out for a period of nine months in a tertiary care hospital of south India. All the patients of either gender diagnosed with ALD were enrolled in the study and patient consent was taken, the data related to the patients of ALD were documented in a structured patient data collection form and analyzed carefully. Results: ALD was mainly affected in male with age group of 41-50 years.Out of 130 patients 43.8% patients were suffered from Fatty Liver disease while 23.1% were suffered from Alcoholic Hepatitis and 33.1% were suffered from Cirrhosis of Liver. The secondary developments to ALD were portal hypertension (13.8%) followed by Ascities (10.8%) and Hepatitis (10%). The major risk factors involved in ALD was alcohol per se (52.3%) and, alcohol and smoking exaggerate the disease condition. The Periodic (61.5%) and regular basis (38.5%) of alcoholism for chronic period of time may land up with ALD. Polypharmacy is essential for the treatment of ALD as it inoved multiple secondary development to ALD. The patients were intervened and counselled on their individual basis for ALD consequences, and motivated for cessation of alcohol and smoking. Conclusion: The study enlightens that the early diagnosis and its beneficial outcomes that can exponentially curtail the mortality rate of ALD. Similarly the optimal drug therapy regimen and patient counseling may improve the patient’s quality of life. Keywords: Alcoholic Liver Disease; Optimal Drug Therapy; Patient Counselling; Improved Quality of Life
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