The occurrence of common subtypes of the Gc^1 gene in a German population
(n = 261) was investigated by isoelectric focusing on thin layers of polyacrylamide in the pH
range 4-6. Six common phenotypes designated Gc IS, IF, 1F-1S, 2-1S, 2-1F, and 2 are considered
as gene products of three common alleles with the following frequencies: Gc^1 = 0.603,
Gc^1F = 0.125, and Gc^2 = 0.272. The sum of the allele frequencies of Gcls and G^1F corresponds
with that of the ‘old’ Gc1 allele. Family investigations are in agreement with an autosomal
codominant way of inheritance. The method employed provides an identification of the subtypes
within 4 h without using anti-Gc-serum for immunoprécipitation.
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