The occurrence of common subtypes of the Gc1 gene in a German population (n = 261) was investigated by isoelectric focusing on thin layers of polyacrylamide in the pH range 4-6. Six common phenotypes designated Gc 1S, 1F, 1F-1S, 2-1S, 2-1F, and 2 are considered as gene products of three common alleles with the following frequencies: Gc1S=O.603, Gc1F=0.125, and Gc2=0.272. The sum of the allele frequencies of Gc1S and Gc1F corresponds with that of the 'old' Gc allele. Family investigation are in agreement with an autosomal codominant way of inheritance. the method employed provides an identification of the subtypes within 4 h without using anti-Gc-serum for immunoprecipitation.
The occurrence of common subtypes of the Gc^1 gene in a German population
(n = 261) was investigated by isoelectric focusing on thin layers of polyacrylamide in the pH
range 4-6. Six common phenotypes designated Gc IS, IF, 1F-1S, 2-1S, 2-1F, and 2 are considered
as gene products of three common alleles with the following frequencies: Gc^1 = 0.603,
Gc^1F = 0.125, and Gc^2 = 0.272. The sum of the allele frequencies of Gcls and G^1F corresponds
with that of the ‘old’ Gc1 allele. Family investigations are in agreement with an autosomal
codominant way of inheritance. The method employed provides an identification of the subtypes
within 4 h without using anti-Gc-serum for immunoprécipitation.
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