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A matched case-control study was performed to identify predictors of mortality among patients (n = 46) with community-onset infections due to extended-spectrum beta-lactamase-producing Escherichia coli in Thailand. The crude mortality rate was 30%. By multivariable analysis, community-onset bloodstream infection due to extended-spectrum beta-lactamase-producing E. coli was the sole predictor of mortality (adjusted odds ratio, 41.3 [95% confidence interval, 4.3-69.4]; [P= .001).

Multivariable Cox regression showed patients with Genitourinary infection (HR: 2.23, p = 0.04) and Implantable devices (HR 11.30, p = 0.17) were at higher risk of death. Conclusion:The site-specific infection has shown to be a significant predictor of mortality in our study, these factors should be taken into consideration and needs further evaluation to understand their specific role in adverse outcome among a cohort of patients diagnosed with sepsis.

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