Clinical and molecular epidemiology of community-onset, extended-spectrum β-lactamase-producing Escherichia coli infections in Thailand: A case-case-control study

Apisarnthanarak, Anucha; Kiratisin, P.; Saifon, Piyawan; Kitphati, Rungrueng; Dejsirilert, Surang; Mundy, Linda M.

doi:10.1016/j.ajic.2007.05.008

Cited by 78 publications

(68 citation statements)

References 40 publications

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“…3 It is well recognized that antimicrobialresistant pathogens are a common cause of hospitalacquired infections; however, an increasing number of community-onset extended-spectrum beta-lactamase (ESBL)-producing bacterial infections, especially those caused by ESBL-Enterobacteriaceae, have been reported in many countries, including Thailand. [4][5][6][7][8][9] Risk factors for acquiring community-onset ESBL-producing Escherichia coli infections in Thailand include prior colonization with the bacterium and previous exposure to third-generation cephalosporins and fluoroquinolones. 9 Fecal carriage of ESBL-producing enterobacteria has increased significantly worldwide, with developing countries (especially in South and Southeast Asia) being the most affected.…”

Section: Introductionmentioning

confidence: 99%

“…[4][5][6][7][8][9] Risk factors for acquiring community-onset ESBL-producing Escherichia coli infections in Thailand include prior colonization with the bacterium and previous exposure to third-generation cephalosporins and fluoroquinolones. 9 Fecal carriage of ESBL-producing enterobacteria has increased significantly worldwide, with developing countries (especially in South and Southeast Asia) being the most affected. In these isolates, CTX-M enzymes are the dominant type of ESBL.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of antibiotic resistant bacteria in healthy adults, foods, food animals, and the environment in selected areas in Thailand

Boonyasiri

Tangkoskul

Seenama

et al. 2014

Pathogens and Global Health

128

110

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Objectives: The aim of this study was to determine the prevalence of antibiotic-resistant bacteria, especially extended-spectrum beta-lactamase (ESBL) producing Escherichia coli, in samples from healthy adults, foods, food animals, and the environment in selected areas of Thailand. Methods: Samples were collected from stool specimens from adult food factory and food animal farm workers, fresh and cooked foods sold at markets, rectal swabs of healthy pigs and chickens, fresh pork meat from slaughterhouses, water samples from canals as well as fish and shrimp farm ponds, and stagnant water sources on pig farms. Antibiotic susceptibility was determined using the disk diffusion or agar dilution methods. Extended-spectrum beta-lactamase production was assayed using a double disk diffusion method. Results: Among 544 healthy adult food factory workers, 75.5% were positive for ESBL producing E. coli, while 77.3% of E. coli isolated from 30 healthy animal farm workers were positive. Amongst healthy food animals, ESBL producing status among E. coli isolates were more commonly detected in pigs (76.7%) than broilers (40%). Extended-spectrum beta-lactamase producing E. coli seemed to be more prevalent in fresh meat samples than in fresh vegetables, in fresh foods than in cooked foods, and in water samples collected from the animal farms than those from canals and fish and shrimp ponds. Conclusions: Extended-spectrum beta-lactamase producing E. coli isolates are prevalent amongst healthy individuals, foods along the food production chain from farms to consumers, and in the environment in selected areas in Thailand.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevalence of antibiotic resistant bacteria in healthy adults, foods, food animals, and the environment in selected areas in Thailand

Boonyasiri

Tangkoskul

Seenama

et al. 2014

Pathogens and Global Health

128

110

View full text Add to dashboard Cite

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“…In the past decade, CTX-M-type ESBLs have replaced TEM-and SHV-type ESBLs in Europe, Canada, and Asia as the most common ESBL type in this species (1,4,19,22,25,30). The United States initially appeared immune to this epidemic of CTX-Mtype ESBLs.…”

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confidence: 99%

Molecular Epidemiology of CTX-M-Producing Escherichia coli Isolates at a Tertiary Medical Center in Western Pennsylvania

Sidjabat

Paterson

Adams-Haduch

et al. 2009

Antimicrob Agents Chemother

119

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A combination of phenotypic and genotypic methods was used to investigate 70 unique Escherichia coli clinical isolates identified as producing extended-spectrum ␤-lactamases (ESBLs) at a medical center in Pittsburgh, PA, between 2007 and 2008. Fifty-seven isolates (81%) produced CTX-M-type ESBLs, among which CTX-M-15 was predominant (n ‫؍‬ 46). Isolates producing CTX-M-2, -9, -14, and -65 were also identified. One CTX-M-producing isolate coproduced CMY-2 cephalosporinase. Ten isolates (14%) produced SHV-type ESBLs, either SHV-5 or SHV-7. Two isolates produced only CMY-2 or -32. Pulsed-field gel electrophoresis revealed the presence of two major clusters of CTX-M-15-producing E. coli isolates, one in phylotype B2 (n ‫؍‬ 15) and the other in phylotype A (n ‫؍‬ 19). Of four phylotype B2 isolates that were able to transfer the bla CTX-M-15 -carrying plasmids, three showed fingerprints related (>60%) to those of plasmids from phylotype A isolates. In phylotype B2, all CTX-M-15-producing isolates, as well as three isolates producing CTX-M-14, two producing SHV-5, and one producing SHV-7, belonged to the international epidemic clone defined by serotype O25:H4 and sequence type 131. The plasmids from eight of nine CTX-M-15-producing E. coli isolates of phylotype A that were examined were highly related to each other and were also found in two isolates belonging to phylotype D, suggesting horizontal transfer of this bla CTX-M-15 -carrying plasmid between phylotypes. Our findings underscore the need to further investigate the epidemiology and virulence of CTX-M-producing E. coli in the United States.

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“…However, no resistance was determined to trimethoprim-sulfamethoxazole in these strains and that can be explained by repeated antibiotic use in patients with chronic obstructive pulmonary disease that usually includes betalactams and quinolones, and not trimethoprim-sulfamethoxazole. These antibiotics lead to the development of resistance to many antibiotics especially in Gram-negative bacilli (27,28).…”

Section: Discussionmentioning

confidence: 99%

Stenotrophomonas maltophilia Infections in Adults: Primary Bacteremia and Pneumonia

Gözel

Çelik

Elaldı

2015

Jundishapur J Microbiol

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Background: Stenotrophomonas maltophilia is the third most frequent non-fermentative Gram-negative bacilli in nosocomial infections, and usually causes severe infections such as primary bacteremia and pneumonia. Objectives: The current study aimed to compare the demographic and clinical characteristics, microbiological findings and final outcomes of the patients with primary bacteremia and nosocomial pneumonia caused by S. maltophilia. Patients and Methods: The current study retrospectively evaluated patients aged 18 years and above with primary bacteremia and nosocomial pneumonia caused by S. maltophilia from January 2006 to December 2013. Medical records of patients, including reports of clinical microbiology and hospital infection control committee, were evaluated. Results: A total of 71 patients with S. maltophilia nosocomial infections, 35 (49.3%) primary bacteremia and 36 (50.7%) pneumonia, were diagnosed. There were no significant differences in gender, age, and co-morbid diseases, except chronic obstructive pulmonary disease; this infection was significantly higher in patients with pneumonia. A slightly higher 14-day mortality was found in patients with pneumonia, but the difference was not statistically significant. Inappropriate antibiotic use and presence of multiple organ dysfunction syndrome were found as independent risk factors for 14-day mortality in multivariate analysis. Conclusions: A slightly higher mortality in patients with pneumonia, caused by S. maltophilia, was strived to explain by advanced age, higher acute physiology and chronic health evaluation (APACHE II) and sepsis related organ failure assessment (SOFA) score, and also higher inappropriate antibiotic use.

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Clinical and molecular epidemiology of community-onset, extended-spectrum β-lactamase-producing Escherichia coli infections in Thailand: A case-case-control study

Cited by 78 publications

References 40 publications

Prevalence of antibiotic resistant bacteria in healthy adults, foods, food animals, and the environment in selected areas in Thailand

Prevalence of antibiotic resistant bacteria in healthy adults, foods, food animals, and the environment in selected areas in Thailand

Molecular Epidemiology of CTX-M-Producing Escherichia coli Isolates at a Tertiary Medical Center in Western Pennsylvania

Stenotrophomonas maltophilia Infections in Adults: Primary Bacteremia and Pneumonia

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