Using an antiserum against a protein, which is electrophoretically a pre-albumin and which has previously been described as occurring specifically in mouse urine, it has been found that this protein occurs in the serum of both male and female mice of various strains, its concentration in the serum being about 200 to 400 times lower than in the urine. In the serum, as in the urine, the concentration of this protein is higher in adult male and testosterone-treated female mice than in infantile male or untreated female mice. In the serum, the values found in these two categories are of the order of 50 to 150 and 10 to 20 μg/ml respectively. Our data indicate that male sex hormone stimulates the production of this protein, which probably originates in the liver and is concentrated and excreted by the kidneys.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.