Senile Changes in the Oestrous Cycle and in Ovarian Structure in Some Inbred Strains of Mice

Boot, L. M.; Mühlbock, O; Thung, P.J.

doi:10.1530/acta.0.0230008

Cited by 83 publications

(44 citation statements)

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“…The infertility of BmprIB-deficient mice is reminiscent of female reproductive senescence. Estrous cycle length increases toward the end of reproductive life as a result of diminishing E2 production (41)(42)(43). Vaginal smear data indicated a prolonged estrous phase in a fraction of BmprIB mutants.…”

Section: Discussionmentioning

confidence: 99%

The type I BMP receptor BmprIB is essential for female reproductive function

LaPolt

Yoon

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

190

109

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Maintenance of female reproductive competence depends on the actions of several hormones and signaling factors. Recent reports suggest roles for bone morphogenetic proteins (BMPs) in early stages of folliculogenesis. A role for the type I BMP receptor BmprIB as a regulator of ovulation rates in sheep has been described recently, but little is known about the roles of BMP signaling pathways in other aspects of reproductive function. We report here that BMPRIB is essential for multiple aspects of female fertility. Mice deficient in BmprIB exhibit irregular estrous cycles and an impaired pseudopregnancy response. BmprIB mutants produce oocytes that can be fertilized in vitro, but defects in cumulus expansion prevent fertilization in vivo. This defect is associated with decreased levels of aromatase production in granulosa cells. Unexpectedly, levels of mRNA for cyclooxygenase 2, an enzyme required for cumulus expansion, are increased. BmprIB mutants also exhibit a failure in endometrial gland formation. The expression of BmprIB in uterine linings suggests that these defects are a direct consequence of loss of BMP signaling in this tissue. In summary, these studies demonstrate the importance of BMP signaling pathways for estrus cyclicity, estradiol biosynthesis, and cumulus cell expansion in vivo and reveal sites of action for BMP signaling pathways in reproductive tissues.

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Section: Discussionmentioning

confidence: 99%

The type I BMP receptor BmprIB is essential for female reproductive function

LaPolt

Yoon

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

190

109

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“…A decline in reproductive capacity with increasing age has been demonstrated in polytocous animals such as rats (Asdell, Bogart & Sperling, 1941), hamsters (Soderwall, Kent, Turbyfill & Britenbaker, 1960) and mice (Thung, Boot & Muhlbock, 1956). The age at which the litter size and frequency of pregnancy decline, varies in different strains of mice (Thung et al, 1956).…”

Section: Introductionmentioning

confidence: 99%

“…The age at which the litter size and frequency of pregnancy decline, varies in different strains of mice (Thung et al, 1956). The onset of relative infertility in old mice precedes termination of oestrous cycles (Jones & Krohn, 1959; Biggers, Finn & McLaren, 1962b), and occurs in most strains which have been studied while the ovary still has many primary oocytes and developing follicles (Jones & Krohn, 1961).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Maternal Age on Ovulation, Corpora Lutea of Pregnancy, and Implantation Failure in Mice

Harman¹,

Talbert²

1970

Reproduction

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Summary. C57B1 female mice aged 4 to 7 months (controls) and 8 to 9, 10 to 11, 12 to 13, and 14 to 15 months were mated and killed at 12 hr, 60 hr or 7\ m=1/ 2\ days post coitum (p.c.). Corpora lutea were counted and evaluated in serially sectioned ovaries. Implantation sites were counted in the animals killed 7\ m=1/ 2\ days p.c. The mean number of implantations in 10-to 11-month-old mice was less than in the control animals. This decrease was closely associated with morphological degeneration of corpora lutea of pregnancy. By 12 to 13 months of age most animals had neither implantation sites nor recognizable corpora lutea of pregnancy 7\ m=1/ 2\ days after mating. These two changes were highly correlated and were not due to a decrease in the number of ovulations as determined by examination of the ovaries of animals killed 12 or 60 hr p.c.It was concluded that the initial decline in fertility with increased maternal age in this strain of mouse may be due to failure of luteal support of the uterus.

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“…These characteristic structures have been noted by several authors after X-irradiation and described as " anovular follicles ". Their origin is unclear and had been ascribed to (a) remnants of small follicles in which the oocytes have degenerated, (b) differentiation of embryonal cells lying dormant in the ovarian stroma or (c) formation from the germinal (surface) epithelium (reviewed by Thung et al, 1956). In the present study empty rings and pseudofollicles have not been observed to be connected with the surface epithelium.…”

Section: Histogenesis Of Ovarian Tumoursmentioning

confidence: 49%

“…With increasing age pigmented cells (Fekete, 1946;Deane and Fawsett, 1952;Thung et al, 1956) appeared in areas of luteinized stroma as well as in corpora lutea, and in old animals pigmented tissue became a prominent structure. Empty rings and pseudofollicles (" anovular follicles ") (Thung et al, 1956;Krarup, 1967) as well as " Sertoli bodies " (Engle, 1946;Thung et al, 1956) were occasionally found in the ovaries of old animals. They were spherical and composed of cells with bright nuclei containing a darkstaining nucleolus and abundant cytoplasm with a reticular structure (Fig.…”

Section: Control Mticementioning

confidence: 99%

Effect of 9,10-Dimethyl-1,2-Benzanthracene on the Mouse Ovary. Ovarian Tumorigenesis

Krarup¹

1970

Br J Cancer

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SUMMARY.-Groups of immature and mature mice were treated once with DMBA by oral or intraperitoneal route, and the subsequent bilateral sequence of ovarian changes leading to the development of unilateral granulosa cell tumour was studied.Early post-treatment changes included disappearance of oocytes and follicles as well as increase of the stroma mass. The neoplastic development was closely correlated to the rate of oocyte disappearance. The faster oocytes were eliminated, the earlier tumours appeared. The early post-treatment changes led to a stage of potential preneoplasia, characterized by diffuse luteinization of the ovarian parenchyma. In some preneoplastic ovaries the luteinized tissue underwent neoplastic transformation and developed into invasive luteoma. In other preneoplastic ovaries foci of granulosa-like tumour cells appeared in the luteinized tissue, representing the stage of microscopic granulosa cell tumour. However, such microtumours could also develop within pre-existing luteomata. Autoradiography after injection of thymidine-3H suggested that the granulosa-like tumour cells developed as the result of undifferentiated proliferation of luteinized cells.So far the pathological ovarian evolution occurred bilaterally as well as unilaterally. However, when a microscopic granulosa cell tumour by further growth became a macroscopic granulosa cell tumour the contralateral ovary invariably atrophied. This ultimate unilateral development coincided with a continuous production of oestrogen by the granulosa cell tumour. The reason for the contralateral atrophy is discussed in relation to the influence of the hormonal balance on ovarian tumorigenesis. THE carcinogenic hydrocarbon 9,10-dimethyl-1,2-benzanthracene (DMBA) administered to sensitive strains of mice affects the ovaries and induces granulosa cell tumours regardless of whether it is applied externally to the skin (Howell et al

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Senile Changes in the Oestrous Cycle and in Ovarian Structure in Some Inbred Strains of Mice

Cited by 83 publications

References 0 publications

The type I BMP receptor BmprIB is essential for female reproductive function

The type I BMP receptor BmprIB is essential for female reproductive function

The Effect of Maternal Age on Ovulation, Corpora Lutea of Pregnancy, and Implantation Failure in Mice

Effect of 9,10-Dimethyl-1,2-Benzanthracene on the Mouse Ovary. Ovarian Tumorigenesis

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