253Table Posthyperglycemic glucose and insulin areas and insulin/glucose area ratios in obese subjects with asymptomatic reactive hypoglycemia and obese control subjects (Mean ± Se) * p < 0.05 Obese hypoglycemics Obese controls Posthyperglycemic glucose area (mg/dl'min) 9,537.5 ± 393.1 * 10,668.1 ± 400.1These data suggest that relative excess in posthyperglycemic insulin secretion in obese hypoglycemic subjects in comparison with obese controls-decreases the ability to maintain glucose homeostasis. This is also supported by the results of McCool, Luqman, Schmitt, Raymundo, Nolan, Stephan, Ah· mad and Danowski (1977) who found that in some instances of reactive hypoglycemia concomitant insulin values were higher than starting levels. However it seems that increased posthyperglycemic insulin area and increased insulin/glucose area ratio are more related to blood glucose nadir than relatively increased rnatched insulin values.Impared insulin-glucose balance in posthyperglycemic period of glucose tolerance test is a strong evidence that asymptomatic reactive hypoglycemia in obesity is not a physiological variation, but, probably, an early diabetic condition.Requests for reprints should be addressed to: M. Solter, M.D.Posthyperglycemic insulin area (uU/ml·min) 8,992.5 ± 756.2* 7,064.7 ± 425.9 ReferencesPosthyperglycemic insulin/ glucose area ratio 0.99 ± 0.13* 0.67 ± 0.05

Diurnal levels of serum triglyceride (TG) were measured in six normal persons consuming a fixed solid 65% fat diet under steady state conditions in a metabolic unit. The food was divided into either three or eight similar portions, differently spaced over the day and night. The diurnal TG-profiles on this diet were practically identical to those found under comparable conditions on a 65% carbohydrate diet [1]. Mean diurnal TG values did not significantly differ with varying meal frequency. Free fatty acid levels, however, were significantly higher on a high fat diet. Post-prandial glucose and insulin reponses did not significantly differ whether a high fat diet or a high carbohydrate diet was consumed. We conclude that the composition of the diet is of little importance in determining diurnal TG patterns when the diet consists of normal food stuffs, but that these patterns are dependent on meal frequency and distribution.