Postprandial Insulin Response and Diurnal Triglyceride Pattern

Abstract

253Table Posthyperglycemic glucose and insulin areas and insulin/glucose area ratios in obese subjects with asymptomatic reactive hypoglycemia and obese control subjects (Mean ± Se) * p < 0.05 Obese hypoglycemics Obese controls Posthyperglycemic glucose area (mg/dl'min) 9,537.5 ± 393.1 * 10,668.1 ± 400.1These data suggest that relative excess in posthyperglycemic insulin secretion in obese hypoglycemic subjects in comparison with obese controls-decreases the ability to maintain glucose homeostasis. This is also supported by the results of McCool, Luqman, Schmitt, Raymundo, Nolan, Stephan, Ah· mad and Danowski (1977) who found that in some instances of reactive hypoglycemia concomitant insulin values were higher than starting levels. However it seems that increased posthyperglycemic insulin area and increased insulin/glucose area ratio are more related to blood glucose nadir than relatively increased rnatched insulin values.Impared insulin-glucose balance in posthyperglycemic period of glucose tolerance test is a strong evidence that asymptomatic reactive hypoglycemia in obesity is not a physiological variation, but, probably, an early diabetic condition.Requests for reprints should be addressed to: M. Solter, M.D.Posthyperglycemic insulin area (uU/ml·min) 8,992.5 ± 756.2* 7,064.7 ± 425.9 ReferencesPosthyperglycemic insulin/ glucose area ratio 0.99 ± 0.13* 0.67 ± 0.05

Circadian Control of Insulin Secretion Is Independent of the Temporal Distribution of Feeding

“…Next to the circadian control over the basal (unstimulated) levels of blood glucose, and insulin and glucose increments, as a consequence of feeding activity, clearly differed depending on the time of day, confirming numerous previous observations in rat and human (1,11,19,20,28,32,39,46,48,52). However, the present study is the first to show unequivocally that the variation in these responses along the 24-h cycle is independent of an unequal distribution of feeding activity.…”

“…Yet another approach to create a constant environment is to present the disruptive (behavioral) stimulus constantly or at regular intervals. In this way too circadian rhythms in plasma glucose and insulin have been described (5,(47)(48)(49)52), though only in human studies. However, rhythms associated with feeding, such as intestinal glucose absorption, may persist for several days, even without food intake (38).…”

Diurnal changes in serum triglycerides as related to changes in lipolytic enzymes, (apo) lipoproteins and hormones in normal subjects on a carbohydrate‐rich diet

“…7 shows the diurnal course of mean serum insulin and glucagon levels. As reported previously [22], insulin exhibited a three peak pattern with higher responses during the first than during subsequent meals. Glucagon decreased after each meal, falling to almost undetectable levels after the third meal, and rose again in the post-absorptive period.…”

Influence of meal frequency on diurnal lipid, glucose and insulin levels in normal subjects on a high fat diet; comparison with data obtained on a high carbohydrate diet

“…Post-prandial glucose and insulin responses were not significantly different from those found on a carbohydrate-rich diet [9]. Neither did we find significant differences in the two subjects who participated in both studies.…”

“…Post-prandial glucose and insulin increments were not significantly different from those found previously [9] in normal subjects on a carbohydrate-rich diet. In the A!…”