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Summary. This paper tlcscrilu'S a prfpanttion consisting of a iiitfd uterine horn with tlie ovariiin n(;r\t's attafhcd. The response to lu-rve stinmiation and to winte drugs depend.s on (he stiiKi' i>f the oestrous cycle.Uteri taken from Ruineii-piRs in dioestroius, in which the vaginal elosure membrane was intact, responded to stimulation of die nerves acxompanying the ovarian vessels witli large fontractinns. Uteri taken from guinea-pins in oe.stroiis, in which the nu-mlmine was absent, responded to stimulation with relnxatiori or irregular ox icc'l>k' coiitriiction.s Noradrcnaline iisiiiilly ciuised ion tract ion of the uterus from animals in dioestroiLs but mtt oi those in oestroiis. Adrenaline caused inhibition and ac:etylcholine contraction of uteri, irrespective of (he stage of the sexual cycle.The response of the dioestrons uterus to nerve stinuilatiim was retliiced by phentolaniine and hy Knanethidine. iiicTOiiseJ by prnpraiiolol and by cocaiiie. and was nnalfected by atropini", hyostine or hexaniethdiiiiui). It is concluded that the fibres stiinulati-d art' post nan ^;]i<)niL• and nuradrenergic. In uteri taken during oestrons the addition of proiiethalol to the bath led to the appearance of contractile responses lo nerve stinmiation, Oestrous uterine homs were often quiescent, while those taken dtiring the remainder of the cycle often exhibited spontaneous activity which griidnally increa.sed during the t'ourst; of an experiment, hnt often increased rapitlly after pheiitolamine or guanethidine wa.s adtled to the buth.The relationship between these results and tlie changing levels of ovarian hormones during the oestrous cyele is discussed.