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HLA-A and HLA-B markers have been determined in fibroblasts grown from tissues of triploid conceptuses and have been tested in the parents. Informative data on the origin of triploidy were obtained in eight cases: diandry I or dispermy in 4 cases, diandry II or dispermy in 2, digyny I or II in 2. This confirms that triploidy involved more frequently two sets of paternal chromosomes.

The polymorphism of HLA antigens was used as a marker to investigate the genetic origin of hydatidiform moles in Senegal. An androgenetic etiology was demonstrated. When both parents shared HLA antigens a preferential inheritance in the mole of the shared specificities was observed. This relative compatibility of the molar conceptus with the mother may be an element of the process that prevents its early rejection.

The close genetic linkage between congenital adrenal hyperplasia (21 OH deficiency) and the HLA B locus has been confirmed in a large series of French families. Two statistically significant, but moderated associations were observed: positive with HLA Bw47 and negative with HLA B8. A strong positive association of late onset with HLA B14 was observed and the results link the trait with HLA loci.

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