no de Tratamiento de l a Leucemia Aguda (GATLA).BsAs.Argentina.This investigation has the following schrmci Inductionrvinc r i s t i n e (~~~)+daunorubicin+~rednisone (PRED); ~m t i o n :i n t r a t h e c a l methotrexatc (MTX)+dexamethasone x b e:rly doses followed by one trimesterly; and Continuation: 6 -m e r~a~t o p u r i n e d a i l y and MTX twice weekly with reinforcement of pulse doses of VCR 1.5 mg/m2 x 1 + PRED 40 mg/m2/day x 7 (arm A) o r VCR+PRED a l t e r n a t i n g with arab. c i t . (Ara.C) 50 mg/m2/sc q. 12 h x 10 + cy~lo~hosphamide (CTX) 600 mg/m2 x 1 (arm B). Pulses a r c performed i n both arms a t 1 , 2 , 3 , 4 , 6 mo. and t r i m e s t e r l y t h e r e a f t e n I n addition, half of t h e cases received levamisole (LEV) 120mg/ m2/oral/daily and the other h a l f , none.From Jan. 1976 t o Dec. 1978, 3 8 p a t i e n t s entered t h i s study.282/322 (88%) children and 44/56 (78%) a d u l t s achieved complete remission (CR) (~( 0 . 6 ) . The % of CR a t 30 mo. a r e , arm A >20.000 leukocytes 4696, 720.000 37% and arm B>X).000 7896, 720.000 3396 (P< 0.01 between and >20.000 leukocytes i n both a m s and P ( O . 6 between arms A and B i n p a t i e n t s uith>20.000 leukocytes). I n addition, 59% of the LEV-treated p a t i e n t s and control group a r e still i n t h e f i r s t CR a t 30 mo. W e conclude t h a t : 1) usefulness of a l t e r n a t i n g reinforcement pulses of VCR+PRED u i t h Ara.GCTX i n r e l a t i o n t o VCR+PRED alom, and 2 ) immunotherapy with LEV is e f f e c t i v e i n prolonging CR.GRAM NEGATIVE SEPSIS OF INFANCY. MECHANISMS OF ACTIVA-TION OF T E CmUMEm SisTm. zelazxo M.E. Labontor i o Central. H t a l . de Nifios. Buenos Aires. Argentina.
Bacterial lipplysaccarides(LPS)fromgram negative organism are a c t i v a t o r s of the a l t e r n a t i v e and c l a s s i c a l pathway of complement(C). This study was undertaken t o evaluate i f t h e r e is an r e l a t i o n between t h e activation i n i t i a t e d by LPS i n v i t r o ad& a c t i v a t i o n of C i n p a t i e n t s v i t h gram negative sepsis. Nine pat i e n t s with bacteremia, endotoxemia(~imulus)and/or hipocanphentemia(CH50) were studied. Levels of ClqlC4,C3,C5 ,C3PA and p r o p e r dine uere measured. LPS from c u l t u r e s uere extracted by the procedure of Westphal.Lipid ~( L~) a n d polysacchariderich f r a c t i o n s (PS)were obtained by acid hydrolisis. W e examined t h e capacity of LPS, LA and PS t o reduce hemolitic a c t i v i t y of N S . I n F e a c t i o n mixtures with the a c t i v a t o r s we performed rmeasu~ements of Clq,C4,antigen B of C3,C5,C3PA and pmperdine; hemolitic C4, nvb i l i t y of C3,C3PA and properdine. Hypocomplementemia was p r d i n 6 p a t i e n t s , t h c C p r o f i l e suggests a c t i v a t i o n of both pathrap in 5 and a l t e r n a t i v e i n 1.Seven LPS reduced hemolitic capacity of NHS and breakdown C?..Different types of a c t i v a t o r s could be distinguished by C4 determinations and rrohility of CjPA.'Ihree LPS a c t i v a t e both pathway...
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