Bleeding Time in Normal Children

Aversa, Luis; Vázquez, Ana Eugenia; Peñalver, Javier; Dascal, E; Bustelo, P

doi:10.1097/00043426-199502000-00004

Cited by 10 publications

(6 citation statements)

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“…[184][185][186] The bleeding time was prolonged, relative to adults, throughout childhood in two of three studies. 34,187,188 Using the platelet function analyzer (PFA)-100 (Dade International, Inc), cord blood samples from term neonates were found to have shorter closure times than samples from older children or adults. [189][190][191] The shorter closure time correlates with the higher hematocrit levels and increased von Willebrand factor activity (measured by ristocetin cofactor assay) in cord blood.…”

Section: Treatment Of Vka-induced Bleedingmentioning

confidence: 99%

Antithrombotic Therapy in Neonates and Children

Monagle

Chan

Goldenberg

et al. 2012

Chest

1,244

559

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Section: Treatment Of Vka-induced Bleedingmentioning

confidence: 99%

Antithrombotic Therapy in Neonates and Children

Monagle

Chan

Goldenberg

et al. 2012

Chest

1,244

559

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“…Bleeding time was estimated by the Duke method using the fingertip technique. 11 The mean bleeding time was compared with that of the pediatric normative data from Aversa et al 12 Gastroesophageal nuclear scintigraphy was performed using a dose of 100 to 200 μCi (3.7-7.4 MBq) of 99m-technetium-sulfur colloid. The isotope was administered in a capsule, which was swallowed with 150 to 300 mL of water.…”

Section: Methodsmentioning

confidence: 99%

Prevalence of smooth muscle dysfunction among children with Duchenne muscular dystrophy

et al. 2020

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Smooth muscle dysfunction in Duchenne muscular dystrophy (DMD) has been rarely studied. A cross-sectional study was conducted to estimate the prevalence of smooth muscle dysfunction (vascular, upper gastrointestinal, and bladder smooth muscle) in children with DMD using questionnaires (Pediatric Bleeding Questionnaire, Pediatric Gastroesophageal Symptom Questionnaire, and Dysfunctional Voiding Symptom Score). Investigations included bleeding time estimation, nuclear scintigraphy for gastroesophageal reflux, and uroflowmetry for urodynamic abnormalities. Ninety-nine subjects were included in the study. The prevalence of vascular, upper gastrointestinal, and bladder smooth muscle dysfunction was 27.2%. Mean bleeding time was prolonged by 117.5 seconds. The prevalence of gastroesophageal reflux was 21%. Voided volume/estimated bladder capacity over 15% and abnormal flow curves on uroflowmetry were seen in 18.2% and 9.7% of the subjects, respectively. Our study highlights the need for addressing issues related to smooth muscle dysfunction in the routine clinical care of patients with DMD.

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“…Normal values for different age groups and for different techniques applied in children are listed in Table 1. 19,22,23,26,27 In newborns, the BT is either similar to or shorter than that of adults. This suggests that the platelet-vessel wall interaction is at least comparable to that of adults, in spite of the reduced platelet function tests in newborns.…”

Section: Normal Values In Pediatricsmentioning

confidence: 99%

“…In pediatric patients there is no difference in the results between the sexes, whereas in adults BT in females is usually longer than in males. 27 A micromethod for BT in the newborn with an Autolet device has been applied also to premature infants. Normal values for newborns were between 3 and 5 minutes.…”

Section: Normal Values In Pediatricsmentioning

confidence: 99%

The Bleeding Time in Pediatrics

Sutor¹

1998

Semin Thromb Hemost

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When performed with standardized methods and techniques, the bleeding time (BT) depends on variables that physiologically alter primary hemostasis. These variables include number of platelets and platelet function, white and red blood cell counts, vascular factors, hormones, and temperature. Variations within normal limits reflect the in vivo situation and are of no clinical relevance. If the BT is prolonged far above the upper normal limit, however, defects of primary hemostasis have to be anticipated. These include thrombocytopenia or thrombocytopathy, anemia, leukopenia, and deficiencies of plasmatic factors such as von Willebrand factor (vWF), fibrinogen, the lupus anticoagulant, and factor V. The BT can be used as screening test for patients with bleeding symptoms. As a single test, the BT gives the best information in pediatrics, in which defects of primary hemostasis are more common than coagulopathies. In addition, BT can guide the therapy of these patients, because it reflects clinical improvement. When used as a preoperative screening test, BT should be combined with the activated partial thromboplastin time (aPTT) because BT usually does not recognize patients with coagulopathies. With standardized techniques and the knowledge of its merits and limitations, BT is a useful test for diagnosing hemostatic disorders, guiding their therapy, and warning of unexpected bleeding complications during surgery. The BT is especially suited for use in pediatrics for the following reasons: (1) It does not require a venipuncture and is similar to capillary blood sampling if performed with standardized devices adapted for pediatric use; (2) it is an in vivo test informing mostly on defects of primary hemostasis, which are the most common bleeding diatheses in childhood; (3) the results are immediately available; (4) it requires only minimal amounts of blood; and (5) it does not require unphysiological reagents and preparation of the sample. The test requires a highly motivated and experienced operator who knows of the many variables influencing the BT. The interpretation cannot be done without knowledge of the history and physical status of the patient and of the limitations of the BT.

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Bleeding Time in Normal Children

Cited by 10 publications

References 0 publications

Antithrombotic Therapy in Neonates and Children

Antithrombotic Therapy in Neonates and Children

Prevalence of smooth muscle dysfunction among children with Duchenne muscular dystrophy

The Bleeding Time in Pediatrics

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