The MMR is widely utilised as an educational tool to promote medical education, patient safety and quality improvement. Although evidence to guide the design and implementation of the MMR to achieve measurable CME outcomes remains limited, there are components associated with positive improvements to learning and performance outcomes.

OBJECTIVE: Despite the high prevalence of mental illnesses and addictions, treatment rates remain low. In April 2010, a regional mass media campaign was implemented to increase awareness of mental health services in central Toronto, Canada. We studied the impact of this campaign on rates of psychiatric emergency department (PED) visits among all hospital emergency departments (EDs) located in Toronto. DESIGN:Monthly PED visit totals were obtained for all Toronto EDs from April 1, 2007 to March 31, 2012. The campaign's impact on visit rates was measured using interrupted time series analysis and a difference-in-difference estimator. We conducted pre-and post-campaign analyses to examine whether volume increases were explained by specific diagnostic categories and/or new presentations (new patients with no prior PED visits), and to examine geographic trends. CONCLUSIONS: Mass media campaigns promoting mental health and psychiatric services can affect health care-seeking behaviour and utilization. Our findings have implications for system-level service planning, which should anticipate volume increases when public mental health campaigns are being considered. RESULTS:KEY WORDS: Health campaign; psychiatry; mental health; addictions; emergency services; interrupted time series analysis La traduction du résumé se trouve à la fin de l'article.

Similar to integrated care clinical interventions, integrated care training is important yet difficult to achieve. Educational initiatives could benefit from faculty development, quality improvement to synergistically improve care and training, and stronger evaluation. Systematic review registration number: PROSPERO 2014:CRD42014010295.

Benassi and Sockalingam argue that it is critical to understand the key ingredients of an intervention along with factors that influence implementation if we are to tanslate medical education research into practice.

SEVERAL facts suggest the existence of a definite relation between the metabolism of aromatic amino acids and mental disease, and between indole compounds and schizophrenia. In recent years, much research has been carried out in the attempt to shed light on this problem. BOCOCH (1957) noted that the administration to 23 schizophrenic patients of a diet deficient in aromatic amino acids for three weeks had marked effects; in 60 per cent of the treated cases the clinical condition deteriorated, while no improvement was noted in the others; these results indicate that the diet tested not only had no therapeutic effect but was apparently detrimental.Concerning tryptophan metabolism (by the kynurenine pathway) ZELLER et al.

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A multicentre trial involving six psychiatric centres was set up in order to evaluate the antidepressant activity of a new compound, maprotiline (Ludiomil®), compared to that of imipramine and amitriptyline. The investigation was carried out according to a double-blind between-patient design; the Hamilton rating scale for depression was used as the main basis for assessment. 135 hospitalized patients entered the trial, 104 presenting endogenous depression and 31 neurotic depression. The results showed that maprotiline is an effective and welltolerated antidepressant drug, its overall activity being quantitatively of the same order as that observed with the reference drugs. The new drug acts particularly favourably in neurotic depression.