lmidazole has been attached at C(2) on the more open face of P-cyclodextrin to mimic the enzyme chymotrypsin; this chemical model is shown to be catalytically far superior to that with an imidazole on the primary side [C(6)] of cyclodextri n.
195 ChemInform Abstract Twelve title compounds of type (III) are prepared and tested for their antiinflammatory, motor and antihypertensive activity. The derivatives (IIIa)-(IIIc) are found to exhibit remarkable antiinflammatory effects; moreover, (IIIa) causes decrease in motor activity with sedation. The derivatives (IIId) and (IIIe) are found to produce a rapid fall in blood pressure.
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