An open, randomized trial was performed to compare the efficacy of three Helicobacter pylori eradication regimens in children with peptic ulcer disease. A total of 106 children (5 - 15 years) were treated for 1 week with metronidazole, 30 - 40 mg/kg per day depending on age, amoxycillin, 750 mg/day, and one of three anti-secretory agents: proprietary omeprazole, 20 - 40 mg/day depending on age; generic omeprazole, 20 - 40 mg/day; or ranitidine, 150 mg twice daily. The H. pylori eradication rate was significantly higher in patients receiving proprietary omeprazole (88.9%) than in those receiving generic omeprazole (80.0%) or ranitidine (74.3%), and this was associated with a trend towards faster ulcer healing. It is concluded that triple therapy consisting of an anti-secretory agent and two antimicrobials produces effective eradication of H. pylori and ulcer healing in children with peptic ulcer disease, and that proprietary omeprazole is more effective than both ranitidine and the generic formulation used in this study.
Th e article is dedicated to the outstanding scientist, doctor, teacher, public fi gu re, co rresponding me mber of the Russian Academy of Sciences, professor, doctor of medical sciences Belousov Yuri, who would have turned 80 on September 23, 2022. The presented materials make it possible to recall the main milestones in the biography of this remarkable person. The article is based on materials collected by relatives, friends, colleagues and students of Yuri Belousov.
In recent years, the problem of resistance of gram-negative microorganisms to carbapenems, as well as the emergence of multiresistant strains is gaining urgency. This problem is of particular importance in neonatal practice due to the age limitations of the use of many antibiotics and the lack of specific recommendations. Local bacteriological monitoring data should be taken into account when selecting a starting antibiotic, and for this purpose, methods of rapid identification of the pathogen and its resistance mechanisms should be introduced. Pediatricians need controlled trials of new antibiotics to successfully treat MDR-Gram-infections.
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