Background: Hidradenitis suppurativa (HS) is a chronic, relapsing inflammatory disease of skin, characterized by recurrent draining sinuses and abscesses, predominantly in skin folds carrying terminal hairs and apocrine glands.Method: This study reviewed 54 sites in 27 patients with moderate to extensive chronic inflammatory skin lesions treated surgically in our hospital from 2004 through 2009, with a follow-up of at least 6 months.Result: A total number of 54 operative procedures were performed during the study period with 42% (23 sites) involving the axilla, 20% (11 sites) involving the gluteal area, %24 (13 sites) involving the perineal area and 12% (7 sites) involving the inguinal region.Conclusion: Conservative treatment methods have little or no effects especially on gluteal, perineal/perianal, axillary hidradenitis suppurativa. The morbidity associated with the established form of this disease is significant, and the only successful treatment is wide surgical excision.
Background aims. Adipose tissue-derived mesenchymal stromal cells (MSCs) have a higher capacity for proliferation and differentiation compared with other cell lineages. Although distraction osteogenesis is the most important therapy for treating bone defects, this treatment is restricted in many situations. The aim of this study was to examine the therapeutic potential of adipose tissue-derived MSCs and osteoblasts differentiated from adipose tissue-derived MSCs in the treatment of bone defects. Methods. Bone defects were produced in the tibias of New Zealand rabbits that had previously undergone adipose tissue extraction. Tibial osteotomy was performed, and a distractor was placed on the right leg of the rabbits. The rabbits were placed in control (group I), stem cell (group II) and osteoblast-differentiated stem cell (group III) treatment groups. The rabbits were sacrificed, and the defect area was evaluated by radiologic, biomechanical and histopathologic tests to examine the therapeutic effects of adipose tissue-derived MSCs. Results. Radiologic analyses revealed that callus density and the ossification rate increased in group III compared with group I and group II. In biomechanical tests, the highest ossification rate was observed in group III. Histopathologic studies showed that the quality of newly formed bone and the number of cells active in bone formation were significantly higher in group III rabbits compared with group I and group II rabbits. Conclusions. These data reveal that osteoblasts differentiated from adipose tissue-derived MSCs shorten the consolidation period of distraction osteogenesis. Stem cells could be used as an effective treatment for bone defects.
abbits' higher sensitivity to infections, stronger muscles and vulnerability to emotional stress require careful and fastidious laboratory practices. Our study consisted of the installment of the Ilizarov fixator on New Zealand white rabbits' tibias and tibia extension via application of Adipose Derived Adult Stem cells (ADAS cells), of which the osteogenic differentiation was applied, to the fracture line. 1,2 We used Ilizarov distractors that were prepared to adjust to rabbit tibia (Figure 1). After a 2 cm incision was made on the anterior tibia, the extensor muscles were exposed and separated from the bone. The exposed bone was cut using a power-operated sur
ÖZETKendi organlarını yeme dürtüsü, toplumda oldukça nadir olmakla birlikte mevcut olan vakalarda da genellikle bu dürtü yumuşak doku ile sınırlı kalmaktadır. Kliniğimize tedavi amaçlı getirilen hastanın ise distal ve orta falanks yumuşak dokusu ile birlikte kemik dokusunu da yemiş olduğu görüldü.
ABSTRACTIn society, the instinct to eat one's own tissues is rare. However it is generally limited to reported cases concerning soft tissue. A patient who was admitted to our department had eaten the distal and middle phalangeal soft tissue along with bone tissue.
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