Capecitabine, a fluoropyrimidine derivative, is an orally administered drug that delivers 5-fluorouracil (5-FU) selectively to the tumour. The drug has demonstrated activity in metastatic colorectal cancer. We describe a male patient receiving capecitabine therapy with typical chest pain and electrocardiographic changes consistent with STsegment elevation myocardial infarction. Capecitabine-induced cardiotoxicity may develop in patients who have had a previous episode of 5-FU-induced cardiotoxicity. Capecitabine-induced cardiotoxicity is a rare condition that may lead to diagnostic and therapeutic dilemmas. (Neth Heart J 2009;17:277-80.).
The biocompatibility of orthopaedic implants and their effects on fracture healing have key roles for success. In this study, it was aimed to investigate the effects of a novel biocomposite consisting of hydroxyapatite (HA), hexagonal boron nitride (h-BN), chitosan (Cs), and type 1 collagen (Ct1) on biocompatibility and fracture healing in rats. A total of 60 adult male Wistar rats weighing 300-500 g were used in the study. The rats were randomly divided into 2 groups named A (uncoated/control) and B (biocomposite coated). Biocomposite (HA/h-BN/Cs/Ct1) coated and uncoated stainless-steel implants were used as intramedullary pins. Groups A and B were divided into subgroups of A1 and B1 (15th day), A2 and B2 (30th day), A3 and B3 (45th day) according to the date of euthanasia. Clinical, radiographic, haematological, biochemical, and histopathological findings were evaluated by pairwise comparisons. The findings were consistent and similar. No statistically significant difference was found for a finding disturbing the biocompatibility. Histopathological examinations showed that coating biomaterials did not resorb over the course of 15, 30, and 45 days. It is thus revealed that the content is biocompatible. However, it has been concluded that it is necessary to increase the physical strength of the coating surface against sterilization and surgical procedures. As a result, based on the interpretations of the clinical, radiographic, haematological, biochemical, and histopathological findings, the biocompatibility of HA/h-BN/Cs/Ct1 biocomposite materials has been revealed.
Materials and Methods A total of 60 adult male, 1-year old Wistar albino rats, each weighing 450-500 g were used in this experimental study. The rats were divid
Nutritional cardiomyopathy in a young camel (C. dromedarius) ÖzBu çalışmada Türkiye'de ilk kez 1.5 aylık dişi bir köşekte (deve yavrusu) (C. dromedarius) nutrisyonel kardiyomiyopati olgusunun makroskobik ve mikroskobik bulguları tanımlan-dı. Konya ili, Karatay İlçe Belediyesi, Hayvanat Bahçesi'nde ölü olarak bulunan deve yavrusunun nekropsisinde, sol epikardda daha belirgin olmak üzere her iki ventrikül ile interventriküler septumda solgun, beyazımsı renkte alanlara rastlandı. Akciğerler oldukça hacimli ve koyu kırmızı renkte, trake ve bronşlarda köpüklü sıvı vardı. Mediastinal ve bronşiyal lenf düğümlerinde büyüme, karaciğerde konjesyon ve tiroid bezinde büyüme gözlendi. Mikroskobik incelemede kalp kasında, hiyalin dejenerasyonu, zenker nekrozu ve yaygın kalsifikasyon, akciğerde konjesyon ile alveollerde yaygın ödem vardı. Karaciğerde hafif hiperemi, bağırsaklarda lamina epitelyaliste dejenerasyon ve deskuamasyon, propriyada nötrofil ve eozinofil granülosit infiltrasyonu gözlendi. Tiroid folliküllerinin epitellerinde hiperplaziye bağlı papiller uzantılar dikkati çekti. Bu bulgular ışığında deve yavrusunda ve/ veya annesindeki beslenme yetersizliği sonucunda beyaz kas hastalığı ve buna bağlı akciğerde dolaşım bozukluğu şekil-lendiği kanaatine varılarak, özellikle hayvanat bahçeleri gibi kapalı ortamlarda bakılan hayvanlara ilave vitamin ve mineral takviyesi yapılmasının uygun olacağı önerilmiştir.Anahtar kelimeler: Köşek, beyaz kas hastalığı, patoloji, nutrisyonel kardiyomiyopati AbstractIn this report, macroscopical and microscopical findings of nutritional cardiomyopathy were firstly described in a 1.5 month old female calf-camel in Turkey. At the necropsy of the young camel, which was found as dead in Konya Karatay Municipality Zoo, pale, whitish colored areas were seen on the epicardium of heart ventricules and interventricular septum. The pale areas were more prominent in the left heart ventricle. Lung was fairly volumed and dark reddish colored, and there was foamy fluid in trachea and bronchi. Mediastinal and bronchial lymph nodes were enlarged, and cut surfaces were dark red colored. Congestion in the liver and enlargement in thyroid glands were also observed. In microscopical examination of the heart muscle, hyaline degeneration, Zenker's necrosis and widespread calcification were determined. In lung, diffuse congestion and edema in alveoli were found. Mild hyperemia in sinusoids of the liver, degeneration and desquamation of lamina epithelialis, neutrophil and eosinophil granulocyte infiltration in lamina propria in small intestine were noticed too. Papillary extensions in epithelium of thyroid follicles due to epithelial hyperplasia were observed. It was concluded from these findings that inadequate nutrition probably caused white muscle disease, resulting in blood circulation disorder in lungs, in the young camel. So, it is advisable to have a vitamin and mineral supplement to animal especially within the enclosed areas like zoos.
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