Introduction: Malaria and HIV are the leading causes of mortality and morbidity in sub-Saharan Africa. The interaction of these two pathologies raises fundamental issues as well as therapeutic. This study seeks a better understanding of the clinical profile of coinfected biological and therapeutic HIV-Malaria in Children's Hospital Pediatrique du jour Day Centre Hospital Universitaire Souro Sanou (CHUSS) Bobo-Dioulasso.Methodology: It about a cross-sectional study with prospective and retrospective aspects. Included, were patients infected with HIV and followed in the service whose clinical and laboratory diagnosis of malaria had been performed and/or patients with whom the diagnosis of co-infection was done with the regression of a medical consultation following the consent of the legal representative. Results:The prevalence of coinfection was 3.09%. The clinical signs of severity were dominated by impaired consciousness, convulsions and dehydration. As for biological signs, anemia was found in 65% of patients; leukocytosis was found in 19.6% of coinfected and thrombocytopenia in 9.3% of cases. HIV-1 was the most encountered serotype and immunocompetent patients accounted for 70.7% of coinfected. Pharmaco therapeutic groups were mainly administered antimalarial (100% of cases), analgesics-antipyretics (79.6% of cases), ART (48.1% of cases), antibiotics, especially cotrimoxazole (21.3% cases). Conclusion:Immunosuppression induced by HIV infection did not appear to be associated with the frequency of occurrence of malaria. Chemo malaria prophylaxis in children living with HIV is not necessary. Consequently, malaria as a reason for consultation could be a gateway for the recruitment of children infected with HIV.