Coinfection HIV and Malaria in Department of Paediatrics of the University Hospital Souro Sanou

Abstract

Introduction: Malaria and HIV are the leading causes of mortality and morbidity in sub-Saharan Africa. The interaction of these two pathologies raises fundamental issues as well as therapeutic. This study seeks a better understanding of the clinical profile of coinfected biological and therapeutic HIV-Malaria in Children's Hospital Pediatrique du jour Day Centre Hospital Universitaire Souro Sanou (CHUSS) Bobo-Dioulasso.Methodology: It about a cross-sectional study with prospective and retrospective aspects. Included, were patients infected with HIV and followed in the service whose clinical and laboratory diagnosis of malaria had been performed and/or patients with whom the diagnosis of co-infection was done with the regression of a medical consultation following the consent of the legal representative. Results:The prevalence of coinfection was 3.09%. The clinical signs of severity were dominated by impaired consciousness, convulsions and dehydration. As for biological signs, anemia was found in 65% of patients; leukocytosis was found in 19.6% of coinfected and thrombocytopenia in 9.3% of cases. HIV-1 was the most encountered serotype and immunocompetent patients accounted for 70.7% of coinfected. Pharmaco therapeutic groups were mainly administered antimalarial (100% of cases), analgesics-antipyretics (79.6% of cases), ART (48.1% of cases), antibiotics, especially cotrimoxazole (21.3% cases). Conclusion:Immunosuppression induced by HIV infection did not appear to be associated with the frequency of occurrence of malaria. Chemo malaria prophylaxis in children living with HIV is not necessary. Consequently, malaria as a reason for consultation could be a gateway for the recruitment of children infected with HIV.

Should we care about Plasmodium vivax and HIV co-infection? A systematic review and a cases series from the Brazilian Amazon

“…HIV can impair immune responses to malaria parasites, and lead to an inability to control parasite clearance, thus resulting in high parasitic loads, which in turn, can increase malaria transmission rates [ 1 , 8 , 9 ]. Clinically, HIV has been shown to contribute to a higher incidence of falciparum malaria [ 10 ], including its severe form, which is characterized by anaemia, cerebral malaria and increased risk of congenital infections [ 11 – 13 ]. The impact of HIV on the severity of malaria appears to be restricted to patients with CD4 + T cell counts < 350 cells/μL [ 10 ].…”

Should we care about Plasmodium vivax and HIV coinfection? A systematic review and a cases series from the Brazilian Amazon

“…Clinically, HIV has been shown to contribute to a higher incidence of falciparum malaria 10 , including its severe form, which is characterized by anemia, cerebral malaria, and increased risk of congenital infections [11][12][13] . The impact of HIV on the severity of malaria appears to be restricted to patients with CD4 cell counts <350 cells/μl 10 .…”

Should we care about Plasmodium vivax and HIV co-infection? A systematic review and a cases series from the Brazilian Amazon

“…Clinically, HIV has been shown to contribute to a higher incidence of falciparum malaria [10], including its severe form, which is characterized by anaemia, cerebral malaria and increased risk of congenital infections [11][12][13]. The impact of HIV on the severity of malaria appears to be restricted to patients with CD4+ T cell counts <350 cells/μl [10].…”