Aim:To describe both the epidemiology and prognosis of people living with HIV (PLHIV) hospitalized in intensive care.Methodology: It is a prospective cross-sectional study conducted at the CHU Sylvanus Olympio, Lomé over a period of 12 months on known HIV infected patients or patients newly diagnosed on admission, from both sexes, aged over 15 years, hospitalized during the period between January 1st and December 31st, 2011. We studied the socio-demographic parameters, the reason for hospitalization, the infections and affections found and and their evolution.Results: During our study period 124 patients (46 men and 78 women) ère selected out of 1130, i.e. a rate of 10.9%, witz a sex ratio of 0.6. The average age of our patients was 41 ± 15.5 years, ranging from 20 years to 69 years. On admission, 41% (51 patients) ère aware of their HIV-positive status, witz 30% on antiretroviral treatment. The reasons for admission ère dominâtes by altered consciousness, repetitive seizures, severe dehydration, severe anemia witz impaired general condition and paroxysmal dyspnées witz respective rates of 48.4%, 22, 6%, 12% 32% and 4.3%. The clinicat manifestations ère dominâtes by hémi corporal sensoriel motor deficit (56.7%), fever (53%) and coma (48.4%). Biologically, 83.6% had a CD4 rate below 200 elements per mm 3 . Anemia was severe in 32 % out of the 87% of cases of anemia. This anemia is associated witz a lymphopenia or neutropenia or thrombocytopenia in respectively 63.3%, 57.1% and 20% of cases. Creatinine and blood urea ère elevated in 20% of cases. Infections and diseases found ère dominâtes by cerebral abscesses (40%), severe anemia (32%), gastroenteritis (12%) and meningitis (11.2%). Brain abscess ère represented by toxoplasmosis in 90% of cases. Meningitis was bacterial in 5 cases (pneumococcus), fungal (Cryptococcus) in 3 cases. Overall mortality was 43% witz a higher lethality for meningitis and severe anemia. Conclusion:The proportion of patients witz HIV infection is high in medical intensive care unit in Togo. The admission patterns are dominâtes by neurological diseases including coma. Infections and/or affections are found but dominâtes by various cerebral abscesses (toxoplasmosis). Mortality in patients witz HIV infection in intensive care is high and seems to be improved by proper management of toxoplasmosis abscesses.
Corresponding author: Ouédraogo S Macaire, Doctor internist to the University hospital Souro Sanou, Department of internal medicine, immunology and hematology Mail box 676, Teaching Higher institute of the health sciences Abstract Introduction: Malaria and HIV are the leading causes of mortality and morbidity in sub-Saharan Africa. The interaction of these two pathologies raises fundamental as well as therapeutic issues. This study seeks a better understanding of the clinical profile of coinfected biological and therapeutic HIV-Malaria in Children's at Hopital Pédiatrique du jour of Centre Hospitalier Universitaire Souro SANOU (CHUSS), Bobo-Dioulasso.Methodology: It is a cross-sectional study with prospective and retrospective aspects. Included, were patients infected with HIV and followed in the department who's clinical and laboratory diagnosis of malaria had been performed and/or patients with whom the diagnosis of co-infection was done at the occasion of a medical consultation following the consent of the legal representative. Results:The prevalence of coinfection was 3.09%. The clinical signs of severity were dominated by impaired consciousness, convulsions and dehydration. As for biological signs, anemia was found in 65% of patients; leukocytosis was found in 19.6% of coinfected and thrombocytopenia in 9.3% of cases. HIV-1 was the most encountered stereotype and immunocompetent patients accounted for 70.7% of coinfected. Pharmaco therapeutic groups were mainly administered antimalarial (100% of cases), analgesics-antipyretics (79.6% of cases), ART (48.1% of cases), antibiotics, especially cotrimoxazole (21.3% cases). Conclusion:Immunosuppression induced by HIV infection did not appear to be associated with the frequency of occurrence of malaria. Chemo malaria prophylaxis in children living with HIV is not necessary. Consequently, malaria as a reason for consultation could be a gateway for the recruitment of children infected with HIV.
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