The NHGRI-EBI GWAS Catalog (www.ebi.ac.uk/gwas) is a FAIR knowledgebase providing detailed, structured, standardised and interoperable genome-wide association study (GWAS) data to >200 000 users per year from academic research, healthcare and industry. The Catalog contains variant-trait associations and supporting metadata for >45 000 published GWAS across >5000 human traits, and >40 000 full P-value summary statistics datasets. Content is curated from publications or acquired via author submission of prepublication summary statistics through a new submission portal and validation tool. GWAS data volume has vastly increased in recent years. We have updated our software to meet this scaling challenge and to enable rapid release of submitted summary statistics. The scope of the repository has expanded to include additional data types of high interest to the community, including sequencing-based GWAS, gene-based analyses and copy number variation analyses. Community outreach has increased the number of shared datasets from under-represented traits, e.g. cancer, and we continue to contribute to awareness of the lack of population diversity in GWAS. Interoperability of the Catalog has been enhanced through links to other resources including the Polygenic Score Catalog and the International Mouse Phenotyping Consortium, refinements to GWAS trait annotation, and the development of a standard format for GWAS data.

The International Mouse Phenotyping Consortium (IMPC; https://www.mousephenotype.org/) web portal makes available curated, integrated and analysed knockout mouse phenotyping data generated by the IMPC project consisting of 85M data points and over 95,000 statistically significant phenotype hits mapped to human diseases. The IMPC portal delivers a substantial reference dataset that supports the enrichment of various domain-specific projects and databases, as well as the wider research and clinical community, where the IMPC genotype–phenotype knowledge contributes to the molecular diagnosis of patients affected by rare disorders. Data from 9,000 mouse lines and 750 000 images provides vital resources enabling the interpretation of the ignorome, and advancing our knowledge on mammalian gene function and the mechanisms underlying phenotypes associated with human diseases. The resource is widely integrated and the lines have been used in over 4,600 publications indicating the value of the data and the materials.

This study assessed the effect of lightweight expanded clay aggregate (LECA) grain size and curing with polyethylene concrete curing film (PCCF) on microstructure, interfacial transition zone (ITZ), and compressive strength of structural lightweight aggregate concrete (LWAC) produced with two different Dmax (16 or 22.4 mm). To this end, 2 series of normal weight aggregate concretes (NWAC) and 6 series of LWAC incorporating 40% by vol. unprewetted LECA having (0-3, 3-8, or 8-16 mm) grain sizes were evaluated by using unit weight, compressive strength tests at 1, 7, and 28 days and SEM-EDX observations. Preventing the moisture loss from fresh concrete through PCCF curing had positive effects on compressive strength up to 14 and 9% for 1 and 28 days respectively. Shell thickness of LECA considerably increased with the decrease in LECA grain size. Thus, the compressive strength of LECA and LWAC increased by the decrease in LECA grain size. LWAC containing 0-3 mm LECA, achieved up to 21% higher compressive strength to weight ratio compared with the NWAC with the aid of the pozzolanic reactivity of fine LECA particles.