Research shows that chronic pain is related to cortical alterations that can be reflected in reduced tactile acuity, but whether acute pain perception influences tactile acuity has not been tested. Considering the biological role of nociception, it was hypothesized that nociceptive pain will lead to a rapid improvement in tactile acuity and that this effect is correlated with pain intensity and pain distribution. In this randomised double-blind controlled experiment (trial no. NCT03021278), healthy participants were exposed to 1 of 3 experimental conditions: acute, nociceptive low back pain induced by saline injection, a sham injection (without piercing the skin) potentially inducing nocebo pain, or no intervention. Tactile acuity was measured by a battery of tests, including two-point discrimination threshold (TPD), before, during the pain experience, and after it subsided. We found that TPD did not improve but deteriorated during pain induction in the experimental group compared with the control group (P < 0.001; η = 0.20) and changed from 56.94 mm (95% confidence interval: 53.43-60.44) at baseline to 64.22 mm (95% confidence interval: 60.42-68.02) during the pain experience. Maximum reported pain was a significant predictor (β = 0.55, P = 0.01) and accounted for 26% of the variance in TPD (P < 0.05). Other tests, point-to-point test and two-point estimation task, changed with a similar trend but did not reach significance. We concluded that acute, nociceptive pain does not improve but deteriorates tactile acuity linearly. The biological role of the observed phenomenon is unknown, and therefore, future studies should address this question.

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Patients with chronic low back pain often report that they do not perceive their painful back accurately. Previous studies confirmed that sensory dissociation and/or discrepancy between perceived body image and actual size is one of the specific traits of patients with chronic pain. Current approaches for measuring sensory dissociation are limited to two-point-discrimination or rely on pain drawings not allowing for quantitative analysis. This case study reports the sensory dissociation of two cases with chronic low back pain using a recently published test (point-to-point-test (PTP)) and a newly developed test (two-point-estimation (TPE)). Both patients mislocalized tactile stimuli delivered to the painful location compared to non-painful locations (PTP test). In addition, both patients perceived their painful lumbar region differently from non-painful sites above and below and contralateral to the painful site. TPE data showed two distinct clinical patterns of sensory dissociation: one patient perceived the two-point distance in the painful area as expanded, while the other patient perceived it as shrunk. The latter pattern of sensory dissociation (i.e., pattern shrunk) is likely to respond to sensory training. Whether enlarged patterns of sensory dissociation are more resistant to treatment remains unknown but would explain the low effectiveness of previous studies using sensory training in chronic low back pain populations. Subgrouping patients according to their sensory discrimination pattern could contribute to the choice and effectiveness of the treatment approach.

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Two-point discrimination (TPD) testing and two-point estimation (TPE) methods are often used to determine tactile acuity, but their reliability is uncertain. Our aim in this study was to assess the reliability of TPD and TPE measurements in the same lumbar spine region of healthy young adults. Participants were 37 young adults (16 females and 21 males; age range: 20–27 years – M age = 21.65, SD = 1.9), who received two tests (TPD and TPE) to determine their tactile acuity. The tests were performed in the lumbar spine area, at the level of the L3 segment, bilaterally, with a 10-minute interval between the measurements. The first test session assessed the reliability of measurements performed by two examiners (inter-rater reliability); and, after 7 days, another examiner repeated the measurements (intra-rater reliability). The reliability of both tests was evaluated using intra-class correlation coefficients (ICC), and results revealed high intra-rater, and inter-rater repeatability for immediate administration of TPD and TPE tests (i.e, after 10 minutes) and moderate repeatability when they were performed at a 7-day interval. Thus, we confirmed high reliability of TPD and TPE assessments of tactile acuity repeated at a short time interval and moderate reliability after 7 days. There was slightly higher reliability for the TPE method.