Background Adiponectin gene (ADIPOQ) polymorphisms have been shown to affect adiponectin serum concentration and some have been associated with breast cancer (BC) risk. The aims of this study were to describe the frequency of single nucleotide polymorphisms (SNPs) of ADIPOQ in Mexican women with BC and to determine if they show an association with it. Methods DNA samples from 397 patients and 355 controls were tested for the ADIPOQ gene SNPs: rs2241766 (GT) and rs1501299 (GT) by TaqMan allelic discrimination assay. Hardy–Weinberg equilibrium (HWE) was tested. Multiple SNP inheritance models adjusted by age and body mass index (BMI) were examined for the SNP rs1501299. Results We found that in the frequency analysis of rs1501299 without adjusting the BMI and age, the genotype distribution had a statistically significant difference (P = 0.003). The T allele was associated with a BC risk (OR, 1.99; 95% CI 1.13–3.51, TT vs. GG; OR, 1.53; 95% CI 1.12–2.09, GT vs. GG). The SNP rs2241766 was in HW disequilibrium in controls. In conclusion, the rs1501299 polymorphism is associated with a BC risk. Conclusions Identification of the genotype of these polymorphisms in patients with BC can contribute to integrate the risk profile in both patients and their relatives as part of a comprehensive approach and increasingly more personalized medicine.
RESUMENAntecedentes: La incidencia de embarazo ectópico es 20/1000 embarazos y en la región cornual se presentan en el 2-4%. La mola hidatiforme ocurre en 1/1000 embarazos en EEUU y 1/500 en México. La presentación simultánea es muy rara. Se han descrito solamente 40 casos en la literatura médica, con una incidencia estimada de 0,04% de localización cornual. Caso clínico: Primigesta de 30 años, que cursando un embarazo de 8 semanas, acude de urgencia por presentar náuseas y vómitos de 1 día de evolución, con dolor abdominal y sangrado vaginal. Prueba de embarazo positiva. A la exploración física presenta dolor abdominal difuso y signos de irritación peritoneal. El ultrasonido transvaginal mostró imagen ecogénica multiquística intrauterina cercana a la región cornual, por lo que se sospecha embarazo molar. En la laparotomía exploradora se realizó resección cornual y posteriormente dilatación y curetaje de la cavidad uterina. La anatomía patológica confirmó el diagnóstico. Negativizó ß-hGC a las 7 semanas después de la cirugía. PALABRAS CLAVE: Embarazo ectópico, embarazo molar, embarazo cornual SUMMARYBackground: The incidence of ectopic pregnancy is 20 per 1,000 pregnancies. The cornual ectopic pregnancy is found in 2-4%. Hydatidiform moles occur in 1 per 1000 pregnancies in USA and 1 per 500 in Mexico. Thus, the incidence of the two occurring together is very rare. Only 40 cases have been reported in the medical literature, the incidence estimate is 0.04%. Clinic case: We analyzed a 30 year old woman patient case, gravida 1, with 8 weeks' gestation by last menstrual period, came at the Hospital Universitario "Dr. José Eleuterio González", Monterrey, Nuevo León, with complaints of nausea and vomiting for 1 day and abdominal pain, and transvaginal bleeding. A cualitative pregnancy test was positive. Physical examination revealed diffuse abdominal tenderness and peritoneal signs. The transvaginal ultrasonography showed a multicystic echogenic mass within the uterus near cornual region consistent with a molar pregnancy. A cornual resection was performed followed by dilation and curettage. Pathologic diagnosis was confirmed. The monitoring of ß-hGC titers was negative 7 weeks after surgery.
Background Taxanes adjuvant therapy is recommended in certain high risk or metastatic tumors, particularly in lung and breast cancer, but also in other types of cancer like ovarian. The incidence of severe adverse drug reactions to paclitaxel is of approximately 10%. Objectives Analyze type I hypersensitivity reactions to paclitaxel and their management in the Mexican population. Method It is a retrospective, observational and descriptive study that included type I hypersensitivity reactions to paclitaxel reported from our database. Symptoms of hypersensitivity reactions to paclitaxel were classified and skin testing was performed with a 6 mg/mL paclitaxel concentration. The desensitization procedure consisted of a 12-steps, 3-bags of 250 mL protocol with a 6–7-hour duration. Results A total of 60 desensitization procedures were performed and were all completed successfully. All participants in our group were female, their median age was 44.5 years. All of our patients had hypersensitivity adverse drug reaction to paclitaxel during their first exposure and within the first 10 minutes of infusion. 63.6% of the patients had a moderate hypersensitivity reaction to paclitaxel and 36.4% had a severe reaction. Conclusions Paclitaxel continues to be a common use drug and has a high rate of adverse drug reactions. This is the first study of hypersensitivity to paclitaxel in a Mexican population.
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