Gramine was isolated from the leaves of Acer saccharinum L., JV,M-dimethyl-5-methoxytryptamine from the bark of Dictyoloma incanescens D.C., bufotenine from the seeds of Piptadenia colubrina Benth., and N, V-dimethyltryptamine from the roots of Mimosa hostilis Benth.Several plants which we have studied recently have, by coincidence, yielded indole alkaloids of simple structure. Four of these are described in the present paper.
NOTESvol. 22 dissolved in 6 ml. of chloroform, and agitated overnight with 1 g. of freshly prepared manganese dioxide. The suspension was diluted with warm chloroform, filtered, washed, and concentrated to dryness. The resulting oil had a strong selective absorption around 240 µ, but could not be crystallized even after chromatography. Acetylation in the usual manner, however, gave 127 mg. of Illb, crystallized from hexane, m.p. 144-147°; X"a'x0H at 237 m,u (e = 15,900
At least one species of the genus Malouetia (Apocynaceae) has been reported to possess extremely toxic properties although the botanical identity of the material still appears to be open to question.1 With this exception, chemical and pharmacological knowledge of the genus is virtually non-existent.
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