This new analytical system provides a rapid and convenient non-invasive method to evaluate skin surface morphology in three dimensions, especially with respect to wrinkle formation. The results obtained using this system provide a deeper insight into the mechanistic relationship between wrinkles and skin elasticity.

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Our results suggest that SHG and the SAAID index are useful indicators of facial skin aging in vivo.

There was a gender-dependent difference in the annual variation of wrinkle depth in subjects around 40 years of age. Seasonal environmental changes may affect on the eye wrinkles depth in men within a year.