Цель -оценка офтальмогипотензивной эффективности метопролола при парентеральном введении в эксперименте. Материал и методы. Проведено 3 серии экспериментов на 24 кроликах. В первой серии под конъюнктиву правого глаза вводили метопролол 0,3 мг однократно. Левый глаз был контрольным. Во второй серии кроликам внутримышечно вводили метопролол 0,5 мг. В третьей серии под конъюнктиву правого глаза вводили метопролол 0,3 мг. В левый глаз инстиллировали 0,5% раствор тимолола однократно. Всем животным проводили тонометрию исходно, а также через 30 мин, 1, 2, 3, 6, 8 и 24 ч. Выполняли биомикроскопию и офтальмоскопию глаз животных исходно, через 1, 3 и 7 сут после введения препарата. Выводы. Максимальное (до 30% от исходного) снижение внутриглазного давления (ВГД) у кроликов получено при внутримышечном введении метопролола. Метопролол, введенный под конъюнктиву кроликам, начинает снижать ВГД быстрее и более эффективно, чем инстилляции тимолола. Офтальмогипотензивный эффект метопролола при введении под конъюнктиву и внутримышечном введении сохраняется более суток. Aim -to evaluate ocular hypotensive efficacy of parenteral metoprolol in an experiment. Material and methods. A total of 3 series of experiments on 24 rabbits were performed. The first series involved a single subconjunctival injection of 0.3 mg of metoprolol in the right eye, while the left served as a control. During the second series the rabbits received 0.5 mg of metoprolol intramuscularly. The third series also implied a subconjunctival injection of 0.3 mg of metoprolol in the right eye, however, supplemented with timolol 0.5% instilled in the left. In all rabbits tonometry was performed before the injection and then in 30 min, 1, 2, 3, 6, 8, and 24 hours. Biomicroscopy and ophthalmoscopy were also performed before and 1, 3, and 7 days after the injection. Conclusions. The maximum reduction (down to 30% from the baseline) of intraocular pressure (IOP) was registered in intramuscular metoprolol rabbits. Subconjunctival metoprolol was associated with a faster and more pronounced decrease in IOP as compared to timolol instillations. In case of local or systemic parenteral administration the hypotensive effect of metoprolol lasts for more than a day.
Для России проблема диагностики, лечения и профилактики инвалидности из-за глаукомы остается актуальной в связи с увеличением ее распространенности среди населения страны [1]. Высокая заболеваемость первичной глаукомой становится социально значимой проблемой для здравоохранения России. Это связано также с высокой частотой глаукомы в структуре болезней органа зрения, частой инвалидизацией больных, со сложностью ранней диагностики глаукомы, значительными затратами бюд
Injuries cause serious disturbance of the form and function of the organ of vision due to the damage and accompanying or remote complications and therefore have a high proportion to the structure of low vision, blindness and disability. One of the complications of penetrating wounds of the eye is iris cysts. Iris cyst can increase and cause pupillary block, secondary glaucoma, uveitis, corneal dystrophy, and therefore it requires surgical intervention. The goal of surgical treatment of an iris cyst is to ensure complete removal of the cyst.Objective: to estimate the clinical and functional results of treatment in a posttraumatic iris cyst, posterior subcapsular cataract and myopic astigmatism patient.Patient and methods. Patient B., 49 years old with posttraumatic retention iris cyst, posterior subcapsular cataract, compound myopic high astigmatism was examined. To determine the tactics of surgical treatment of the patient, a complex of General ophthalmology was perfomed (visometry, IOP measurement, autorefractometry, biomicroscopy, ophthalmoscopy), as well as special (B-scanning, optical coherence tomography of the retina) research methods. The follow-up period was 1 year.Results and discussion. To improve visual functions and prevent the development of secondary glaucoma, the patient was offered surgery - excision of the iris cyst and cataract phacoemulsification with toric intraocular lens. Simultaneous carrying out of two stages of the operation reduced the risks of postoperative complications and shorten the rehabilitation period.Conclusion. Positive optical and therapeutic effects were achieved as a result of the surgical treatment 44 years after an open eye injury: the eye is calm, the iris cyst is not detected, visual acuity has increased. The postoperative period showed the saving the stable and high visual and functional result with no recurrence of the iris cyst.
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