Scale drop disease virus (SDDV) is the causative agent of scale drop disease (SDD), a newly emerging disease of farmed Asian sea bass, Lates calcarifer in Singapore, Indonesia, Malaysia and Thailand (Gibson-Kueh et al., 2012; de Groof et al., 2015; Nurliyana et al., 2020; Senapin et al., 2019). SDDV is a double-stranded DNA virus, having an icosahedral shape (140-180 nm diameter), with a reported incomplete genome size of 124,244 bp (de Groof et al., 2015). The virus is currently classified as a novel Megalocytivirus, one of the five genera within the family Iridoviridae (de Groof et al., 2015). The major capsid protein encoding gene of SDDV had a ~64%-65% nucleotide identity to other members in the same genus including infectious spleen and kidney necrosis virus (ISKNV), red seabream iridovirus (RSIV) and turbot reddish body iridovirus (TBIV) and 73.28% identity to a newly identified
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