An efficient and environmentally benign method has been developed for the synthesis of 5arylidine-2-(methylthio)-thiazolones derivatives using Alum [KAl(SO4)2•12H2O] catalyst and triethyl amine in water under microwave irradiation. This green transformation generated one C-S and one CC bond, condensation and S-methylation. Notable advantages for the present protocol include, short reaction time, cleaner reaction profile and easy isolation of product by microwave irradiation technique using green catalyst and solvent.
The kinetics of DMSO (dimethylsulphoxide) assisted one pot cyclocondensation of bisanilino disulphide and 1,3-dicarbonyls has been investigated using spectral method. The kinetic measurements have been carried by varying media, temperature and concentration of the reactants. The assistance of DMSO is investigated. The order of reaction, effects of substituents with dicarbonyls on the rates and thermodynamic parameters has also been reported. First time reaction conditions are optimised for performing the cyclocondensation conveniently and rapidly. Probably mechanism has been proposed and order of reaction was determined on the basis of rate expression and was in agreement with second order rate equation, used for the determination of rate constants.
This study describes a straightforward, efficient, one-step, environmentally friendly synthesis of 2-aminothiazoles. This green procedure was catalyzed using an Iodic Acid catalyst and PEG-400 as green solvent. The synthesized compounds were characterized by 1H NMR, 13C NMR and HRMS analyses. Keywords: 2-aminothiazoles, Iodic acid, PEG-400: H2O
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