Rapid and efficient one-pot microwave-assisted synthesis of 2-phenylimidazo[1,2-<i>a</i>]pyridines and 2-phenylimidazo[1,2-<i>a</i>]quinoline in water–PEG-400

Jadhav, Santosh; Shioorkar, Mahesh G.; Chavan, Omprakash S.; Sarkate, Aniket P.; Shinde, Devanand B.

doi:10.1080/00397911.2016.1262040

Cited by 13 publications

(3 citation statements)

References 30 publications

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“…[188] Jadhav et al in 2017 reported an effective and environmental friendly one-pot method for the synthesis of 2-phenylimidazo[1,2-a]pyridines 248 from substituted acetophenones 246, 2-aminopyridine derivatives 247 and succinamide 239 in presence of iodine with green solvent PEG-400 and water. [189] They developed this method under microwave irradiation with an excellent yield of product in a very short reaction time by avoiding the use of hazardous solvents (Scheme 72).…”

Section: Microwave-assisted Reactionsmentioning

confidence: 99%

Recent Advances in the Synthesis of Imidazo[1,2‐a]pyridines: A Brief Review

et al. 2022

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This review focuses on providing comprehensive highlights of the recent synthetic pathways of imidazo[1,2‐a]pyridines, assisted through transition metal‐catalyzed reactions, multi‐component reactions, cyclization, condensation, microwave‐assisted reactions, heteroannular and photocatalytic reactions. Among the heterocyclic groups, imidazo[1,2‐a]pyridines are considered as privileged structures because of their occurrence in many natural products. In this review, we have summarized the recent advances in the synthesis of imidazo[1,2‐a]pyridines from 2016 to 2021 from various substrates. This review will provide new initiatives to the chemists towards the synthesis of imidazo[1,2‐a]pyridines and all frequent challenges associated with the reported methods.

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Section: Microwave-assisted Reactionsmentioning

confidence: 99%

Recent Advances in the Synthesis of Imidazo[1,2‐a]pyridines: A Brief Review

et al. 2022

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“…White solid, mp 137-139 °C; lit. 45 9.1 Hz, 1H), 7.2 -7.1 (m, 1H), 7.0 -6.9 (m, 2H), 6.7 (tq, J 6.6, 1.2 Hz, 1H), 3.8 (d, J 1.1 Hz, 3H). NMR 13 General procedure for the synthesis of 3-selanylimidazo[1,2-a]pyridines 5a-q.…”

Section: -Phenylimidazo[12-a]pyridine (3a)mentioning

confidence: 99%

Ultrasound-assisted synthesis of imidazo[1,2-a]pyridines and sequential one-pot preparation of 3-selanyl-imidazo[1,2-a]pyridine derivatives

Vieira¹,

Padilha²,

Nascimento³

et al. 2019

Arkivoc

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A simple and rapid method to synthesize imidazo[1,2-a]pyridines starting from 2-aminopyridine and 2bromoacetophenone derivatives under ultrasonic irradiation was developed. This protocol tolerates a wide range of 2-bromoacetophenone derivatives to produce a variety of imidazo[1,2-a]pyridines in good to excellent yields. Additionally, the one-pot preparation of 3-(organylselanyl)imidazo[1,2-a]pyridines via a sequential method is presented. In this case, different diorganyl diselenides were used as starting material s to afford the corresponding coupling products in excellent yields and short reaction times under sonication. The reactions were conducted in PEG-400, a cheap and nontoxic solvent, compatible with the ultrasound conditions in an environmentally benign process.

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“…Under these circumstances, microwave‐assisted chemistry appears to be a promising synthetic method . Utility of microwave irradiation to carry out organic reaction has now become a regular feature. The main benefits of performing the reaction under microwave conditions are the significant rate enhancements and the higher product yields with minimum time requirement.…”

Section: Introductionmentioning

confidence: 99%

A Facile Synthesis of Substituted 2‐(5‐(Benzylthio)‐1,3,4‐oxadiazol‐2‐yl)pyrazine Using Microwave Irradiation and Conventional Method with Antioxidant and Anticancer Activities

Patil

Sarkate

Karnik

et al. 2019

Journal of Heterocyclic Chem

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A series of novel substituted 2‐(5‐(benzylthio)‐1,3,4‐oxadiazol‐2‐yl)pyrazine derivatives (6a–n) were synthesized under microwave irradiation and conventional conditions with less reaction time with good to excellent yields. All the synthesized compounds were screened for antioxidant and anticancer activities. Out of the 14 prepared derivatives, compounds 6f and 6m were most potent and active with antioxidant and anticancer activities, respectively. Also, the developed technique was simple, easy, and less time consuming.

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Rapid and efficient one-pot microwave-assisted synthesis of 2-phenylimidazo[1,2-a]pyridines and 2-phenylimidazo[1,2-a]quinoline in water–PEG-400

Cited by 13 publications

References 30 publications

Recent Advances in the Synthesis of Imidazo[1,2‐a]pyridines: A Brief Review

Recent Advances in the Synthesis of Imidazo[1,2‐a]pyridines: A Brief Review

Ultrasound-assisted synthesis of imidazo[1,2-a]pyridines and sequential one-pot preparation of 3-selanyl-imidazo[1,2-a]pyridine derivatives

A Facile Synthesis of Substituted 2‐(5‐(Benzylthio)‐1,3,4‐oxadiazol‐2‐yl)pyrazine Using Microwave Irradiation and Conventional Method with Antioxidant and Anticancer Activities

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