The present work aims to study the influence of antioxidants activity of lion's foot (Alchemilla vulgaris) leaves at different concentrations to give more protection against chronic liver disease. Results indicated that dried lion's foot leaves had rich in total polyphenolic and flavonoids content (395.65 and 183.10 mg/100g, respectively). These results were reflected to the antioxidant activity (DPPH); it's noticed that the antioxidant activity of dried lion's foot leaves was high (131.74%). The major polyphenolic components were benzoic acid (1084.63 ppm) followed by ellagic acid, catechol, and catechin (614.16, 580.54, and 566.53 ppm, respectively) then salicylic acid and protocatechuic acid (479.71 and 444.43 ppm, respectively). On the same trend, flavonoids fractions indicated the highest content in luteo-6-arabinase 8-glucose, apig. 6-rhamnase 8-glucose, acatein, narengin and luteolin (40.01; 15.04; 8.07; 6.64 and 6.42 ppm, respectively). Fifty-six male albino rats were used in biological experiments. Rats fed on basal diet for two weeks before the performance of the experiment. At the beginning, rats divided into eight main group were fed on diets for 45 days as follows: Negative control group (first group) was fed on basal diet. Forty nine rats were fed on basal diet and induced by CCl 4 , in paraffin oil (50% v/v, 2 ml/Kg) twice weeks subcutaneous injection to induce chronic damage in the liver, then divided into 7 groups numbered from group 2 to group 8. Positive control group rats fed on basal diet till final experiment (second group). Group 3 and 4 rats treated with 50 and 100 ppm ethanolic leaves extracts, respectively. Also, group 5 and 6 treated with 50 and 100 ppm aqueous leaves extracts, respectively. All extracts were fed on orally every day. While, rats in group 7 treated with 1% and 2% dried lion's foot leaves. At the end of the experimental period, serums were collected to determine liver and
Dandelion is a common plant widely used in many countries for its nutritional and medicinal benefits. The main target of this study was to investigate its effect in two different concentrations (2.5% & 5%) on blood lipids in male albino rats. The experiment was carried out using twenty-eight male albino rats. These rats were put on basal diet for one week before being divided into four main groups (seven rats each). Group 1: Negative control group continued basal diet during the whole experiment. Group 2: Positive control group was fed on basal diet for 28 days, then injected with Oxytetracycline for three consecutive days (120 mg/kg body weight) and continued on the basal diet till the end of the experiment. Group 3: continued as group 2 and after being injected rats were given Dandelion powder 2.5 % on the basal diet. Group 4: as the same of group 3 except that rats were given 5 % Dandelion powder. The study continued for one week after the injection of Oxytetracycline. At the end of the experimental period rats were fasted overnight and sacrificed; blood samples were collected from the aorta to determine lipids profiles. Besides, the biological parameters were recorded. The study concluded that diet fortified at 2.5% and 5% dandelion powder helped to improve blood lipid levels in rats compared with positive control groups (injected with oxytetracycline).
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.