We recommend surgical treatment as soon as possible in children with hydatid cysts located in the right middle lobe and lingula to prevent the risk of perforation.

In this study, we investigate a new fractional-order mathematical model which considers population dynamics among tumor cells-macrophage cells-active macrophage cells, and host cells involving the Caputo fractional derivative. Firstly, the stability of the positive steady state of the model is studied. Subsequently, the conditions for existence and uniqueness of the solutions are examined. Then, the least squares curve fitting method (LSCFM) which is one of the prominent methods for parameter estimation is used to fit the parameters of the model. It is aimed to fit the relevant parameters with the help of the tumor tissue samples which were collected from the patient with non-small cell lung cancer who had chemotherapy-naive hospitalized at Kayseri Erciyes University hospital in Turkey. A total of 12 parameters in the model are estimated using the data of lung tumor cells of this patient for 14 days. Moreover, the numerical simulations are given by considering the different fractional orders and different parameters for the model. So, it is achieved how the change in $$\alpha $$ α affects the dynamic behavior of the system. In the sequel, to point out the advantages of the fractional-order modeling, the memory trace and hereditary traits are taken into consideration. Finally, the interpretations in terms of biological science are provided in conclusion. We believe that this interdisciplinary study will open new doors for other similar studies and will shed light on the studies to be developed on the use of real data in the mathematical modeling of cancer.

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BackgroundHydatid cyst disease is still a problem in many countries. Surgical removal is currently the generally accepted choice of treatment for lung hydatidosis. However, operating on bilateral widespread lung hydatidosis is still controversial. The aim of this retrospective study was to evaluate the results of surgical treatment in bilateral multiple hydatid disease of the lung.MethodsIn this study, we reviewed our experience in the surgical treatment of 17 (3.7%) patients with bilateral, and at least three, lung hydatid cysts. These 17 patients (8 male, 9 female), with an average age of 34.6 years (range 12–58 years), underwent bilateral staged thoracotomy.ResultsIn total 105 lung cysts were removed from 17 patients who underwent staged thoracotomies. The mean count of cysts was 6.7 (range 3–20 cysts). Most of the cysts (38.2%) were located in the right lower lobe. The mean interval between thoracotomies was 4.2 (range 3–5) days. Two patients (11.7%) had cysts associated with hepatic hydatidosis and one (5.8%) had cysts associated with the spleen; they were treated via phrenotomy during thoracotomies. All cysts were removed without lung resection. We observed some complications such as prolonged air leaks (n = 2), atelectasis (n = 3) and empyema (n = 2). No further surgery was required for management of complications. The mean hospital stay was 9.3 days. (range 7–23 days). Oral albendazole was started on the 2nd post operative day after the first thoracotomy in the dose of 10–20 mg/kg and was continued for 3 months with a gap of 1 week after each 21 days. No recurrences or deaths occured during the follow-up period.ConclusionsAlthough staged thoracotomy applied in 3–5 days after the initial thoracotomy increases the total hospital stay, it decreases the chance of possible complications can occur in cysts in the other lung when long intervals are preferred between the first and the second thoracotomy. In our experience, bilateral staged thoracotomy is an appropriate surgical option because morbidity rates are minimal and the hospital stay is acceptable for the treatment of bilateral widespread lung hydatidosis, even in patients who had a total of 20 hydatid cysts.

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C-TBNA is a useful diagnostic procedure for sampling intrathoracic lymphadenopathies and masses that are adjacent to the bronchial system. An observational education programme is helpful for learning C-TBNA. The diagnostic yield improves in time, and approximately 30 procedures may be sufficient to achieve successful results.

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Introduction It is not always easy to diagnose pulmonary neuroendocrine tumors (PNET).The aim of the present study is to make a differential diagnosis by studying the same markers in patients with non-small-cell lung carcinoma (NSCLC), patients with benign lung disease (chronic obstructive pulmonary disease and pneumonia) and healthy volunteers to determine the roles of these markers in pulmonary neuroendocrine tumors (PNET) diagnosis and to identify their power. Methods A total of 100 participants including 23 PNET patients and 28 NSCLC patients who were pathologically diagnosed but not yet treated, 25 participants with benign disease and 24 healthy volunteers were included in this cross-sectional study. Results No significant difference was found between the chromogranin A (CgA)and squamous cell carcinoma antigen 1 (SCCA1) values among the groups (PNET - NSCLC - Benign - Healthy volunteers)but the difference in progesterone-releasing peptide (Pro-GRP), neuron-specific enolase (NSE) and adjusted NSE was statistically significant (P values were respectively Pro-GRP p = 0.006, NSE p = 0.015, NSE adjusted p = 0.09).In a comparison of the PNET-NSCLC groups, having a Pro-GRP value higher than 84.6 pg / mL revealed PNET with 60.9% sensitivity and 89.3% specificity (p=0.001). Conclusion The Pro-GRP value is the only indicator that distinguishes the PNET group from the other 3 groups.