These findings support the hypothesis of MDMA-induced protracted alterations of the serotonergic system and indicate that the reduced availability of serotonin transporter, as measured by PET, might be reversible. Women appear to be more susceptible than men to MDMA-induced alterations of the serotonergic system.
Background: PentixaFor is a promising radiopharmaceutical for positron emission tomography in the detection of different tumor entities and other diseases. Until now, the synthesis of [ 68 Ga]Ga-PentixaFor was reported for the automated synthesis module from Scintomics® only. Our aim was to evaluate the automated synthesis of this radiopharmaceutical on a different module in order to make it available for a broader community. Results: The synthesis of [ 68 Ga]Ga-PentixaFor with different amounts of PentixaFor (50 μg, 30 μg and 20 μg) on the Modular Lab PharmTracer (MLPT) from Eckert & Ziegler with the already established synthesis template for [ 68 Ga]Ga-DOTATOC yielded best results with 50 μg PentixaFor for clinical multi-dose application. All different quality control parameters tested (e.g. sterility, stability and radiochemical purity) were in accordance with the European Pharmacopoeia. Conclusions: [ 68 Ga]Ga-PentixaFor was successfully synthesized fully-automated on the synthesis module Modular Lab PharmTracer and can be used for multi-dose application in clinical settings.
A new two step procedure for the synthesis of methyl 2,3-anhydro-a-D-lyxofuranoside and methyl 2,3-anhydro-b-D-ribofuranoside from D-xylose involving the intramolecular Mitsunobu reaction is presented. Likewise, methyl 2,3-anhydro-a-L-lyxofuranoside is obtained from L-arabinose. Cyclic sulfites with D-ribo configuration, synthetic equivalents of the corresponding anhydrosugars, are prepared in three steps from D-ribose.
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