Fully-automated production of [68Ga]Ga-PentixaFor on the module Modular Lab-PharmTracer

Abstract

Background: PentixaFor is a promising radiopharmaceutical for positron emission tomography in the detection of different tumor entities and other diseases. Until now, the synthesis of [ 68 Ga]Ga-PentixaFor was reported for the automated synthesis module from Scintomics® only. Our aim was to evaluate the automated synthesis of this radiopharmaceutical on a different module in order to make it available for a broader community. Results: The synthesis of [ 68 Ga]Ga-PentixaFor with different amounts of PentixaFor (50 μg, 30 μg and 20 μg) on the Modular Lab PharmTracer (MLPT) from Eckert & Ziegler with the already established synthesis template for [ 68 Ga]Ga-DOTATOC yielded best results with 50 μg PentixaFor for clinical multi-dose application. All different quality control parameters tested (e.g. sterility, stability and radiochemical purity) were in accordance with the European Pharmacopoeia. Conclusions: [ 68 Ga]Ga-PentixaFor was successfully synthesized fully-automated on the synthesis module Modular Lab PharmTracer and can be used for multi-dose application in clinical settings.

Cold Kit Labeling: The Future of 68Ga Radiopharmaceuticals?

“…Chemokine receptor 4 (CXCR4) is overexpressed in numerous tumor types, and plays a critical role in tumor growth and invasiveness, as well as metastasis ( 206 ). The 68 Ga-labeled CXCR4 antagonist ([ 68 Ga]-Pentixafor), prepared automatically through a commercial single-use cassette ( 207 ), has revealed itself as a useful clinical tool in hemotologic diseases and in solid tumors, as well as under benign conditions ( 208 – 210 ). Fibrobast activation proteins (FAPs), overexpressed in a variety of tumors, are involved in several tumor-promoting activities and represent a prospective theranostic target.…”

Potential novel imaging targets of inflammation in cardiac sarcoidosis

“…Pentixafor is a proprietary molecule by SCIENTOMICS GmBH which needs to be radiolabeled with 68Ga (using a generator). 91 Imaging characteristics are shown in Table 1.…”

Recent Breakthrough in 68Ga-Radiopharmaceuticals Cold Kits for Convenient PET Radiopharmacy

“…has been mainly prepared using automated modular system either of Scintomics Germany or more recently by Modular Lab PharmTracer (MLPT) from Eckert & Ziegler Eurotope GmbH. 97 68 Ga-FAPI (fibroblast activation protein inhibitor) targeting FAP overexpression in cancer-associated fibroblasts of several tumor entities (breast, colon, pancreatic cancer, etc.) has demonstrated promising results and is in phase II clinical trials.…”

“…It is either prepared manually or by modular approach. , 68 Ga-pentixafor targeting chemokine receptor-4 (CXCR4) involved in several biological processes (angiogenesis, proliferation, metastasis) and overexpressed in many solid tumors (breast, prostate, lymphoma, pancreatic cancer, etc.) has been mainly prepared using automated modular system either of Scintomics Germany or more recently by Modular Lab PharmTracer (MLPT) from Eckert & Ziegler Eurotope GmbH …”