Symptomatic improvements reported for dietary treatment in EGE by most of the available literature are questionable because of the lack of objective evaluation of clinical changes and the very limited assessment of histological remission. Because of the relative lack of well-designed, high-quality studies, the unequivocal use of dietary treatment for patients with EGE and colitis cannot be supported. Further research should be undertaken.
Rotavirus is a major burden on the Spanish Healthcare System. Rotarix Ò and RotaTeq Ò were simultaneously commercialized in Spain by February, 2007. The objective is to analyze the incidence and seasonality of rotavirus hospitalizations (RH) in Castile-La Mancha (CLM), following the first 3 y of commercialization. A cross-sectional study of the hospital discharge registry's Minimum Basic Data Set (
Fluorescent flow cytometry performance has recently spread for urine screening. However, controversy about cytometer results can be drawn from medical literature. This study shows the diagnosis accuracy of Sysmex UF-1000i analyzer by means of a group of decision rules encompassing both demographic variables (age) and cytometer parameters (bacteria, leucocytes and bacteria morphology). After applying the predictive algorithm, the UF-1000i could optimally identify 95% urinary tract infections with high negative predictive value and low diagnostic error. Implementation of UF-1000i would avoid culturing almost 38% of urine samples, thus reducing time to diagnosis, unnecessary antibiotic treatments and consequently improving cost-effectiveness.
Objective: To identify a body fat percentage (%BF) threshold related to an adverse cardiometabolic profile and its surrogate BMI cut-off point. Design: Cross-sectional study. Setting: Two public schools in poor urban areas on the outskirts of Guatemala City. Subjects: A convenience sample of ninety-three healthy, prepubertal, Ladino children (aged 7-12 years). Results: Spearman correlations of cardiometabolic parameters were higher with %BF than with BMI-for-age Z-score. BMI-for-age Z-score and %BF were highly correlated (r = 0·84). The %BF threshold that maximized sensitivity and specificity for predicting an adverse cardiometabolic profile (elevated homeostasis model assessment-insulin resistance index and/or total cholesterol:HDL-cholesterol ratio) according to receiver operating characteristic curve analysis was 36 %. The BMI-for-age Z-score cut-off point that maximized the prediction of BF ≥ 36 % by the same procedure was 1·5. The area under the curve (AUC) for %BF and for BMI data showed excellent accuracy to predict an adverse cardiometabolic profile (AUC 0·93 (SD 0·04)) and excess adiposity (AUC 0·95 (SD 0·02)). Conclusions: Since BMI standards have limitations in screening for adiposity, specific cut-off points based on ethnic-/sex-and age-specific %BF thresholds are needed to better predict an adverse cardiometabolic profile.
ObjectiveTo examine correlations of body mass index (BMI) or % total body fat (%TF) with metabolic biomarkers of chronic disease risk and to explore differences in prevalence of overweight according to BMI‐based definitions by WHO, CDC, and IOTF criteria.MethodsWe measured anthropometry, %TF (DXA), lipid profile, and insulin resistance in a convenience sample of 95 Guatemalan Ladino children 7–12 y‐old. We compared Spearman correlation coefficients of BMI vs. %TF with metabolic biomarkers. Next, we compared the prevalence of overweight as estimated using WHO, CDC, or IOTF criteria.ResultsCorrelations of %TF with HOMA‐IR (r=0.64), total cholesterol‐to‐HDL ratio (r=0.60), and triglycerides (r=0.55) were higher than those of BMI (r=0.60, 0.54, and 0.50, respectively). The correlation of %TF with BMI was 0.84. Prevalence of overweight according to WHO, CDC, and IOTF criteria was 44%, 38% and 40%, respectively (p < 0.001).ConclusionsPrevalence of overweight varies according to BMI‐based criteria. Since %TF is more strongly related to metabolic parameters than BMI, a formal evaluation of BMI‐based definitions of childhood overweight is warranted in this population.Source of Research Support: Global Health Initiative, Collaborating Centers of Excellence, NHLBI
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