Decline in rotavirus hospitalizations following the first three years of vaccination in Castile-La Mancha, Spain

Redondo, Olga; Cano, R.; Simón, Lorena

doi:10.1080/21645515.2015.1009339

Cited by 9 publications

(23 citation statements)

References 34 publications

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“…Altogether, 23 006 case records were retrieved: bacterial or parasitic AGEs (001-007, and 008•0-008•5), viral AGEs (008•6-008•8), and AGEs of unknown etiology: 'undetermined cause' (009•0-009•3), 'unspecified non-infectious AGE' (558•9), or 'diarrhea' (787•91), any of which entered into any of the primary or secondary diagnosis fields (SDFs) [4]. The Information and Sanitary Statistics Service of the Counsel for Health and Social Welfare in CLM provided us with the MBDS, specifically including the corresponding DRGs attributable to rotavirus.…”

Section: Design Setting and Data Sourcementioning

confidence: 99%

“…Rotavirus is the most frequently identified agent of infectious acute gastroenteritis (AGE) in unvaccinated children under 5 years of age [1][2][3][4]. It is associated with significant morbidity and cost across Western Europe [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…Still, scientific publications on costs analyses of DRGs in infectious diseases in Europe are scarce despite their growing importance for determining hospital reimbursement [23][24][25][26][27][28]. Specifically, a national estimate of reduction in costs following the decrease in rotavirus hospitalizations [4,19] has not been estimated to date.…”

Section: Introductionmentioning

confidence: 99%

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Impact of self-financed rotavirus vaccines on hospital stays and costs in Spain after a 3-year introductory period

González

Tenias²,

Ruiz-Gonzalo

2017

Epidemiol. Infect.

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Vaccination has reduced rotavirus hospitalizations by 25% in European regions with low-moderate vaccine availability. We aimed to quantify the reduction in hospital costs after the longest period in which Rotarix® and Rotateq® were simultaneously commercially available in Spain. Cases, length of stay (LOS), and diagnosis-related groups (DRGs) were retrieved from the Minimum Basic Data Set. Healthcare expenditure was estimated through the cost accounting system Gescot®. DRGs were clustered: I, non-bacterial gastroenteritis with complications; II, without complications; III, requiring surgical/other procedures or neonatal cases (highest DRG weights). Comparisons between pre (2003-2005)- and post-vaccine (2007-2009) hospital stays and costs by DRG group were made. Rotaviruses were the most common agents of specific-coded gastroenteritis (N = 1657/5012). LOS and extended LOS of rotaviruses fell significantly in 2007-2009 (β-coefficient = -0·43, 95% confidence intervals (95% CI) -0·68 to -0·17; and odds ratio 0·62, 95% CI 0·50-0·76, respectively). Overall, costs attributable to rotavirus hospitalizations fell approximately €244 per patient (95% CI -365 to -123); the decrease in DRG group III was €2269 per patient (95% CI -4098 to -380). We concluded modest savings in hospital costs, largely attributable to cases with higher DRG weights, and a faster recovery. A universal rotavirus vaccination program deserves being re-evaluated, regarding its potential high impact on both at-risk children and societal costs.

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Section: Design Setting and Data Sourcementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of self-financed rotavirus vaccines on hospital stays and costs in Spain after a 3-year introductory period

González

Tenias²,

Ruiz-Gonzalo

2017

Epidemiol. Infect.

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“…Concomitant AGE cases were defined as having any of the bacterial, parasitic, or viral AGE codes in the SDF. The algorithm explaining the final count has been described elsewhere [16].…”

Section: Definition Of the Variable Of Interestmentioning

confidence: 99%

A multifactorial regression analysis of the features of community-acquired rotavirus requiring hospitalization in Spain as represented in the Minimum Basic Data Set

González

Tenias²

2016

Epidemiol. Infect.

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Over 10% of acute rotavirus gastroenteritis (ARGE) requires hospitalization because of complications. The aggravating factors have been widely analysed, but in an isolated way. We aimed to explore the interrelationship between the clinical and epidemiological factors that characterize rotavirus hospitalizations in Spain using information from the Minimum Basic Data Set (MBDS). Using ICD-9-CM codes, we classified acute gastroenteritis (AGE) cases by principal diagnosis fields and then categorized their comorbidities, complications, and epidemiological features by secondary fields. A multivariable, logistic, step-wise regression model was then constructed. We identified 1657 ARGE cases from 17 415 cases of AGE. Rotavirus hospitalizations were associated with place of residence, age, and season (P < 0·0001), as well as with dehydration [odds ratio (OR) 12·44, 95% confidence interval (CI) 1·52-40·38], intravenous rehydration (OR 1·74, 95% CI 1·29-2·35), metabolic acidosis (OR 1·51, 95% CI 1·24-1·83), respiratory tract infections (RTIs) (OR 1·60, 95% CI 1·09-1·98), and concomitant AGE (OR 1·52, 95% CI 1·03-2·25). Dehydration was four times more likely in patients aged <5 years (OR 4·36, 95% CI 1·20-12·96) and was associated with acidosis when ARGE and RTI were present simultaneously (P < 0·0001). Specific co-infecting viruses may play a role in acute respiratory symptoms and aggravation of gastrointestinal manifestations of rotaviruses, thus leading to complications requiring hospitalization.

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“…Currently, 98 countries have introduced RV vaccines into their national immunisation programs. (3) This measure has had a major impact on the burden of AGE, decreasing RV outpatient visits and hospitalisations by 60%-90% in Europe (4) (5) (6) (7), Although in Spain RV vaccines are recommended by the Spanish Paediatric Association but not funded by the National Health System (NHS), several post-authorization studies have also shown their effectiveness and impact on AGE and RV-AGE hospitalisations (8) (9) (10) (11) (12). The Valencia Region of Spain could show a specific coverage-related impact of RV vaccines on AGE and RV-AGE hospitalisations and costs, despite the low-medium vaccine coverage (40%-50%).…”

Section: Introductionmentioning

confidence: 99%

Spatio-temporal impact of self-financed rotavirus vaccination on rotavirus and acute gastroenteritis hospitalisations in the valencia region, spain.

López-Lacort

Orrico-Sánchez

Martínez-Beneito

et al. 2020

Preprint

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Background Several studies have shown a substantial impact of Rotavirus (RV) vaccination on the burden of RV and all-cause acute gastroenteritis (AGE). However, the results of most impact studies could be confused by a dynamic and complex space-time process. Therefore, there is a need to analyse the impact of RV vaccination on RV and AGE hospitalisations in a space-time framework to detect geographical-time patterns while avoiding the potential confusion caused by population inequalities in the impact estimations. Methods A retrospective population-based study using real-world data from the Valencia Region was performed among children aged less than 3 years old in the period 2005-2016. A Bayesian spatio-temporal model was constructed to analyse RV and AGE hospitalisations and to estimate the vaccination impact measured in averted hospitalisations. Results We found important spatio-temporal patterns in RV and AGE hospitalisations, RV vaccination coverage and in their associated adverted hospitalisations. Overall, ~1866 hospital admissions for RV were averted by RV vaccination during 2007–2016. Despite the low-medium vaccine coverage (~50%) in 2015-2016, relevant 36% and 20% reductions were estimated in RV and AGE hospitalisations respectively. Conclusions The introduction of the RV vaccines has substantially reduced the number of RV hospitalisations, averting ~1866 admissions during 2007-2016 which were space and time dependent. This study improves the methodologies commonly used to estimate the RV vaccine impact and their interpretation.

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Decline in rotavirus hospitalizations following the first three years of vaccination in Castile-La Mancha, Spain

Cited by 9 publications

References 34 publications

Impact of self-financed rotavirus vaccines on hospital stays and costs in Spain after a 3-year introductory period

Impact of self-financed rotavirus vaccines on hospital stays and costs in Spain after a 3-year introductory period

A multifactorial regression analysis of the features of community-acquired rotavirus requiring hospitalization in Spain as represented in the Minimum Basic Data Set

Spatio-temporal impact of self-financed rotavirus vaccination on rotavirus and acute gastroenteritis hospitalisations in the valencia region, spain.

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