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Detection of nerve agent-related molecules based on BODIPY-salicylaldehyde oxime conjugation was studied. Fluorescence intensity of the B-SAL-OXIME species increases in the presence of DECP, whereas it decreases in the presence of DCP and DEMP (limit of detection = 997 nM). Benzonitrile formation in the novel fluorescent B-SAL-OXIME system was elucidated using model substrates.

A novel rechargeable meso-aryl Bodipy-based Cys sensing ensemble has been developed (''turn on,'' U F = o0.05 -0.72, limit of detection = 6.0 Â 10 À6 M) with exceptional selectivity over homocysteine, N-acetylcysteine, glutathione (GSH) and methionine.Recently, detection and chemosensing of sulphur-containing amino acids and peptides have attracted considerable attention as they play essential and unique roles in biological systems. 1 Abnormal levels of biological thiols can lead to several health problems. For example, elevated concentration of homocysteine (Hcs) in human plasma is associated with human diseases such as Alzheimer's disease and cardiovascular disease; 2 cellular glutathione (GSH) deficiency leads to oxidative stress and is linked to several diseases including certain neurodegenerative disorders, cancers and AIDS. 3 The deficiency of cysteine (Cys) may be involved in symptoms as wide ranging as liver damage, edema, hair depigmentation, lethargy, muscle and fat loss, and skin lesions. 4 Thus, selective detection of biological thiols continues to be of great interest. Various detection methods include HPLC, capillary electrophoresis, electrochemical methods, mass spectrometry, and UV-Vis and fluorescence spectroscopy. In particular, advances in molecular fluorescence chemosensing are widely sought due to its simplicity, high sensitivity and compatibility for thiol detection 5 in real biological samples. 6 Several Bodipy fluorophores have been developed for thiol sensing; however, their detection mode is often based on a chemical reaction between fluorophore and analyte. 7 Although systems utilizing non-covalent interactions between fluorophore and thiol have been reported, 8 Bodipy-based ensembles have not yet been explored in this context. Herein, we report a new ''turn-on'' fluorescence Bodipy-based Cu 2+ chemosensing Scheme 1 Depiction of the transformations required to obtain compounds 1 and 2.