Introduction. Primary immune thrombocytopenia is a rare disease1. The incidence of ITP is not well estimated in Russia and worldwide. In adults it varies from 1,6 to 3,9/100 000 person-years2-3. The gender and age-associated results are discussed and differ in several investigations4-6. Study objectives: evaluation of the incidence of primary immune thrombocytopenia in adults in one region of Russia Patients and methods. The data source is the Registry of the patients with primary ITP in Russia. 272 adult patients: 77 males (28%) and 195 females (72%), age from 16 to 89 years (median 44 years) with ITP (ICD-10 code D69.3), newly diagnosed cases during the period from 12 Jan 2014 to 24 May 2016. Results. 221 (81%) cases were newly diagnosed in 12 regions of Russia in which registration was performed most actively - more than 5 cases for the duration of the study. But only one region was selected for the first evaluation of epidemiological characteristics because of the number of reasons. There is one hematological central clinic in this region in which diagnosis of ITP can be verified and patients with ITP are treated and monitored most properly. The early started and fully performed registration process can be regarded as covered most part of region population in this target region. 86 cases (27 male, 59 female) were registered in the target region. The gender-age distribution was following: male: age <41 = 10 (37%), age <41-60 = 7 (26%), age >60 = 10 (37%); female: age <29 = 10 (49%), age <41-60 = 15 (25%), age >60 = 15 (25%). The estimated incidence rate in the target region is shown in table 1. The estimated incidence rates in gender-age strata in the target region are demonstrated in table 2. Conclusion. Overall ITP incidence in one region of Russia is 3.20/100 000 person-years. It is compatible to the incidence in other European countries. Our data demonstrate the rise of incidence rate in males with age and its decrease with age in female population. Literature. 1) Rodeghiero F., Stasi R., Gernsheimer T., Michel M., Provan D., Arnold D.M., et al. Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from international working group. Blood. 2009; 113(11): 2386--93. doi: 10.1182/blood-2008-07-162503. 2) Terrell DR, Beebe LA, Vesely SK, Neas BR, Segal JB, George JN. The incidence of immune thrombocytopenic purpura in children and adults: A critical review of published reports. Am J Hematol. 2010; 85(3): 174-180. 3) Moulis G, Palmaro A, Montastruc J-L, Godeau B, Lapeyre-Mestre M, Sailler L. Epidemiology of incident immune thrombocytopenia: a natiowide population-based study in France. Blood. 2014; 124(22): 3308-3315. 4) Segal JB, Powe NR. Prevalence of immune thrombocytopenia: analyses of administrative data. J Thromb Haemost 2006; 4: 2377-83 5) Schoonen WM, Kucera G, Coelson J, et al. Epidemiology of immune thrombocytopenic purpura in the General Practise Research Database. Br J Haematol 2009; 145(2): 235-244. 6) Lisukov I.A., Maschan A.A., Shamardina A.V., Chagorova T.V., Davydkin I.L., Sycheva T.M., et al. Immune thrombocytopenia: clinical manifestations and response to therapy. Intermediate analysis of data of the Russian register of patients with primary immune thrombocytopenia and review of literature. Oncogematologiya. 2013; 2: 61--9]. Disclosures No relevant conflicts of interest to declare.
This article describes the results of a study of 128 cats with urological syndrome. The study was conducted to determine the incidence of this syndrome, its nosological structure, analysis of clinical signs, as well as laboratory data characteristic of this syndrome. The data were obtained from the patients of the clinical branches of the DSTU, Rostov-on-Don, the patients had not been treated anywhere before and were first seen with urological syndrome of cats. A medical history was compiled for all cats, a clinical examination was carried out, and blood and urine were collected for analysis. As a result of the studies, it was revealed that as part of the urological syndrome, idiopathic cystitis of cats occurred in 65% of cases, urinary tract infections in 14% of cats, obstruction of the urethra caused by urethral plugs was observed in 68%, urolithiasis in 28%, and only in In 0.7% of cats, proliferative changes in the urethral tract were noted. In 79% of cats with urological syndrome, it was accompanied by urethral obstruction with different mechanisms of occurrence.
Feline lower urinarytract disease (FLUTD) is a life-threatening condition in cats, especially in obstructive males. In a clinical situation, early diagnosis and correction of this condition is very important, otherwise the disease ends in death. FLUTD manifested by stranguria, pollakiuria, dysuria, and, in severe cases, hematuria and obstruction by anuria. This article discusses the features of the clinical course of FLUTD in 5 cats with obstructive idiopathic cystitis. Animals were selected with a similar history, they were animals from 3 to 7 years old, with exclusively home keeping, no walking and a diet consisting of dry commercial food. All animals underwent a complete clinical examination, complete blood count, general urinalysis, ultrasound of the genitourinary system and heart. For two weeks, the animals underwent a complex treatment consisting of infusion therapy, anesthesia with dexmedetomidine and NSAIDs (meloxicam), which led to clinical recovery in all animals within 14 days, all animals on an ongoing basis were prescribed amitriptyline, observation of the animals for 6 months did not reveal a relapse of the disease.
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