Objective: Sarcoidosis is a multisystemic disease, exact cause of disease is unknown but it is assumed that genetic predisposition and ethnic factors play a role in etiology. Studies related with familial sarcoidosis is limited and only case reports about familial sarcoidosis is available from our country. We aimed to evaluate the prevelance of familial sarcoidosis and clinical findings of cases with familial sarcoidosis.
Methods:We retrospectively documented file records of 678 patients diagnosed with sarcoidosis and followed up in outpatient clinic of sarcoidosis from January 1996 to February 2016. 28 familial sarcoidosis cases in 14 families were enrolled into the study. Their demographic findings, family relationship, symptoms, laboratory and pulmonary function test results, radiological apperances, diagnostic methods, treatments were recorded.Results: Twenty-eight sarcoidosis patients out of 678 reported as familial cases, giving a prevelance of familial sarcoidosis as 4%. There were 8 sarcoidosis sib, 4 sarcoidosis mother-child, 1 sarcoidosis father-child and 1 sarcoidosis cousin relationship. Female/male ratio was 1.8, mean age of the study population was 43, most freguent symptoms were cough and dyspnea, stage 2 was mostly seen according to chest X-ray, most common CT appearance was mediastinal lymphadenopathy and mediastinoscopy was the most freguent diagnostic method.
Conclusion:This study is important to lead interrogation of family in patients with suspected sarcoidosis and future studies investigating familial aggregation in sarcoidosis.
Objective: Tuberculosis (TB) is an infection that can involve all tissues and organs. Although pulmonary TB (PTB) is more common, extrapulmonary TB (EPTB) is still a major clinical problem. The incidence of EPTB is 35.1% and in recent years; there has been an increase in EPTB case reporting in our country. In this study, we retrospectively investigated the clinical and laboratory characteristics of rare EPTB cases. Methods: The study included rare EPTB patients diagnosed and/or followed up in our clinic. Cases with pleural TB and lymph node TB were excluded from the study. The diagnosis of EPTB was made by clinical, microbiological and/or histopathological and/or radiological findings and response to treatment. The demographic features, clinical findings and laboratory values were recorded from patient files, and were evaluated in terms of EPTB. Results: Fifty patients were included in the study (mean age=34±15.8 years, female/male=33/17). The most frequently involved organ was peritoneum (n=13, 26%). There was multi-organ involvement in 4 cases (8%). Coexistence of EPTB with PTB was determined in 9 cases (18%). Four patients had a history of TB and 14 had a history of contact with TB. All the cases were human immunodeficiency virus-negative, and one case was hepatitis B surface antigen positive. The major complaints were abdominal pain, weight loss, night sweats, fever, and cough. Twenty-three patients had normal chest radiographs and the mean duration of treatment was 9 months. Conclusion: TB is a serious public health problem in Turkey as well as all over the world. Since it is a treatable disease, early diagnosis and treatment have utmost importance for avoiding the serious complications of rare EPTB forms.
yılında, dünyada yaklaşık 10,4 milyon yeni tüberkü-loz (TB ) ve 480.000 yeni çok ilaça dirençli TB (ÇİD-TB) hasta sayıları ile; TB ciddi bir halk sağlığı sorunu olarak öne çıkmaktadır. Aynı yılda, 1,4 milyon kişinin TB nedeni ile öldüğü ve bu hastaların 340.000'inin ÇİD-TB tanılı olduğu hesaplanmıştır.1,2 Bu ne- A An na ah h t ta ar r K Ke e l li i m me e l le er
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