Objective: Sarcoidosis is a multisystemic disease, exact cause of disease is unknown but it is assumed that genetic predisposition and ethnic factors play a role in etiology. Studies related with familial sarcoidosis is limited and only case reports about familial sarcoidosis is available from our country. We aimed to evaluate the prevelance of familial sarcoidosis and clinical findings of cases with familial sarcoidosis.
Methods:We retrospectively documented file records of 678 patients diagnosed with sarcoidosis and followed up in outpatient clinic of sarcoidosis from January 1996 to February 2016. 28 familial sarcoidosis cases in 14 families were enrolled into the study. Their demographic findings, family relationship, symptoms, laboratory and pulmonary function test results, radiological apperances, diagnostic methods, treatments were recorded.Results: Twenty-eight sarcoidosis patients out of 678 reported as familial cases, giving a prevelance of familial sarcoidosis as 4%. There were 8 sarcoidosis sib, 4 sarcoidosis mother-child, 1 sarcoidosis father-child and 1 sarcoidosis cousin relationship. Female/male ratio was 1.8, mean age of the study population was 43, most freguent symptoms were cough and dyspnea, stage 2 was mostly seen according to chest X-ray, most common CT appearance was mediastinal lymphadenopathy and mediastinoscopy was the most freguent diagnostic method.
Conclusion:This study is important to lead interrogation of family in patients with suspected sarcoidosis and future studies investigating familial aggregation in sarcoidosis.
The skin is the second most commonly involved organ after pulmonary system in sarcoidosis, a multisystemic granulomatous disease. Cutaneous small-vessel vasculitis (leukocytoclastic vasculitis [LCV]) is a disorder characterized by neutrophilic inflammation of small blood vessels. Although the skin is the organ where LCV is seen most frequently, extracutaneous involvements are also seen. Herein, we present a coexistence of sarcoidosis and cutaneous LCV, which is an uncommon condition in adult.
The utility of NLR determined at initial diagnosis in predicting disease stage and discriminating between active and stable disease in patients with sarcoidosis : Cross-sectional study.
Backgroud: The incidence of HIV/AIDS infection is gradually increasing. One of the organs, which this infection targets, is the lungs. The lung involvement is seen in forms of recurrent pneumonia, pneumocystis jiroveci pneumonia, tuberculosis, and Kaposi sarcoma.
Aim:The aim of this study is to draw attention on the importance of this subject while examining the cases, which we follow up in hospital.
Study design:The data were obtained from the files and hospital records of all of HIV (+) patients, who have been hospitalized in our hospital in last 10 years.
Methods: a retrospective studyResults: On the contrary with literature, most of our HIV (+) patients were diagnosed for P.jiroveci pneumonia. For the patients applying with complaints of cough, fever, and dyspnea and then found to have deep hypoxia and extensive infiltration in lung and oral candidiasis in physical examination, P.jiroveci pneumonia should be considered, thoracic CT -HRCT should be immediately taken and HIV test should be performed. Starting the accurate therapy as soon as possible significantly affects the clinical course. For the patients diagnosed for tuberculosis, the HIV serology should be requested, and consequently the antiretroviral treatment should be initiated according to the results.Conclusions: According to our study, 83% of the positivity of HIV was determined through the respiratory system complications of this infectious disease. It was aimed to draw attention to this infectious disease having increasing incidence, and to raise awareness that performing the required laboratory tests affects the prognosis.Moreover, 4 patients known to be HIV (+) gave no information on this subject in anamnesis. According to the practice of Ministry of Health, HIV serology shall not be performed unless the approval of patient is obtained. But, this also poses risk for the healthcare professionals. We believe that the required legal regulations taking healthcare professionals under protection should be prepared.
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