The aim: To perform a retrospective analysis of leptospirosis morbidity in Ivano-Frankivsk region, to give the etiological characteristics of leptospirosis according to clinicallaboratory parameters, to determine the peculiarities of the course, prognostic features. Materials and methods: Data of the State Enterprise “Ivano-Frankivsk Regional Laboratory Center of the Ministry of Health of Ukraine”, reports and abstracts of medical records of the Regional Clinical Infectious Diseases Hospital for 2009-2018 were used. Clinical observation of patients, analysis of general-clinical, biochemical, and serological indices were carried out. Results: The leptospirosis morbidity in Ivano-Frankivsk region during 2009-2018 was higher than in general in Ukraine. Activation of foci of leptospirosis L. pomona and grippotyphosa in 2009-2013, decrease of L. grippotyphosa and increase of L. pomona foci and “new” L. autumnalis, australis, bataviae, cynopteri in 2014-2018 were noted. The emergence of leptospirosis L. autumnalis, which had a high virulence and caused a severe course, was noted. Conclusions: The leptospirosis morbidity in the Ivano-Frankivsk region over the past 10 years has exceeded the incidence in Ukraine and varied within 0.62-2.2 per 100,000. During the last 5 years, the serological structure has changed: L. pomona (27.7%) prevailed, L. grippotyphosa decreased (2.1%), L. bataviae and cynopteri, autumnalis increased (by 8.5%). Seasonality is shifted in the autumn-winter period (November-February) (L. grippotyphosa, australis, pomona, canicola). According to forecasts, leptospirosis induced by L. autumnalis was most adverse. Leptospiroses of serogroups L. australis, bataviae, cynopteri had a mild course, there were fewer complications.
The aim: To study the clinical and epidemiological peculiarities of measles in adults according to the data of the Regional Clinical Infectious Disease Hospital in Ivano-Frankivsk, Ukraine. Materials and methods: The article analyzes the epidemiological and clinical features of 113 cases of measles among adults who undergone inpatient treatment in 2017-2018. The diagnosis was confirmed by the detection of antiviral Ig M antibodies. Determination of the genotype of the virus was performed in Regional WHO Reference Laboratory in Luxembourg. Results: The genotype of the measles virus was MVs/Cambridge GBR/5.16 D8 is circulating through the region territory. In 98.3% of adult patients a typical clinical picture of moderate severity was observed. Measles was accompanied by complications such as acute bronchitis (23.9%), reactive hepatitis (13.3%), reactive pancreatitis (10.6%) and pneumonia (7.1%). Сonclusions: The following epidemiological peculiarities in adult patients with measles: young people are mostly ill, urban residents are not vaccinated, partly vaccinated or with an unknown vaccine status. There was a change in the genotype of the virus of measles circulating in the Ivano-Frankivsk region: in 2012 genotype MVs/ManchesterGBR/10.09D4 was confirmed, now the genotype of the measles virus is MVS/ CambridgeGBR/5.16D8. In 98 (86.73%) patients was a typical clinical picture of the disease, of moderate severity. Among the complications of the disease were diagnosed: bronchitis and pneumonia (23.9% and 7.1% respectively), reactive hepatitis and reactive pancreatitis (13.3% and 10.6%).
The aim: To determine changes of FSG of neutrophilic granulocytes of peripheral blood (NGPB) of patients with CHC with concomitant DM-2. Materials and methods: We’ve examined 180 patients with CHC: 160 with concomitant diabetes mellitus and 20 ones without it. The NGPB genome was studied using cytogenetic method. There were analyzed 100 interphase NGPB nuclei in the preparation, structural characteristics were evaluated according to indices: chromatization (IC), nucleolar (IN), pathologically altered nuclei (PAN), micronuclei (MNI). Results: Violations of FSG OF NGPBwere found according to all indices in patients with CHC, they were more pronounced in patients with concomitant DM-2. Conclusions: FSG NGPB is more disordered in CHC with concomitant DM-2. The reduction of IC in CHC with concomitant DM-2 is more pronounced in men. Reduction of IN in patients with CHC with and without DM-2 is a marker of violations of the second stage of realization of hereditary information. The tendency to change the components of the cytogenetic status of all examined patients due to the frequency of MNI was determined.
Parasitic diseases remain an important problem today. Recently, many cases of combined invasion have been registered. Mixed invasion by Giardia and roundworms is the most common in Ukraine. The clinical picture of the disease is characterized by damage to various organs and systems, but most often in patients the manifestations relate to the primary site of parasitism of pathogens - the gastrointestinal tract, which is often accompanied by disruption of the intestinal microflora. The aim was to study the effect of probiotics containing bicarbonate saccharomycetes in the complex therapy of patients with giardiasis, ascariasis, and combined invasion. We examined 90 patients with giardiasis, ascariasis, and combined invasion, divided into 3 groups, depending on the type of invasion, each of which is divided into two subgroups, depending on the treatment (basic treatment and with the addition of probiotics). It was administered orally 1 capsule 2 times a day for 14 days. 1 capsule contains 250 mg of saccharomycetes and excipients. The control group consisted of 20 healthy individuals. The state of the intestinal microflora was determined using a classical microbiological study of feces to determine the population level of the microflora according to VA Znamensky. The research was performed twice: before treatment and 14 days after treatment. The diagnosis of giardiasis and ascariasis was confirmed by detection of the pathogen in the feces by parasitoscopy of feces. When studying the state of the intestinal microflora, it was found that all patients had the following changes before treatment. The content of bifidobacteria, lactobacilli, enterococci and the total content of E. coli was reduced. At the same time, there was an increase in the content of peptococci, bacteroids, Escherichia coli with weakly enzymatic properties, haemolytic Escherichia coli, fungi of the genus Candida and staphylococci. After the basic treatment, some positive changes were observed in all groups of patients, but the content of autochthonous flora still decreased, the presence of pathogenic bacteria (staphylococci) and fungal flora was noted. The content of bifidobacteria was slightly reduced. The quantitative composition of lactobacilli was higher than before treatment. Patients had a reduced amount of bacteroids, total Escherichia coli, although its content was higher than before treatment. An elevated level of Escherichia coli with weak enzymatic properties was noted. Hemolytic Escherichia coli was present, as well as the number of enterococci. Fungi of the genus Candida were available also. In the 3b group of patients there were more significant signs of improvement in the microflora. After the inclusion in the treatment complex of probiotics containing saccharomycetes of billard, according to the results of bacteriological research, there was a significant positive dynamic of the intestinal microflora. The content of bifidobacteria was significantly higher compared to the other two groups. The quantitative composition of lactobacilli was slightly reduced. The amount of bacteroids was normalized. The total content of Escherichia coli increased, there was a decrease in the content of Escherichia coli with weak enzymatic properties. In addition, the presence of haemolytic Escherichia coli was detected in only one patient. Almost complete normalization of the level of enterococci was observed. From the fungal flora, the level of fungi of the genus Candida was minimal, comparing similar results of other groups.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.