IntroductionMeaningful patient engagement (PE) can enhance medicines’ development. However, the current PE landscape is fragmentary and lacking comprehensive guidance.MethodsWe systematically searched for PE initiatives (SYNaPsE database/publications). Multistakeholder groups integrated these with their own PE expertise to co-create draft PE Quality Guidance which was evaluated by public consultation. Projects exemplifying good PE practice were identified and assessed against PE Quality Criteria to create a Book of Good Practices (BOGP).ResultsSeventy-six participants from 51 organisations participated in nine multistakeholder meetings (2016–2018). A shortlist of 20relevant PE initiatives (from 170 screened) were identified. The co-created INVOLVE guidelines provided the main framework for PE Quality Guidance and was enriched with the analysis of the PE initiatives and the PE expertise of stakeholders. Seven key PE Quality Criteria were identified. Public consultation yielded 67 responses from diverse backgrounds. The PE Quality Guidance was agreed to be useful for achieving quality PE in practice, understandable, easy to use, and comprehensive. Overall, eight initiatives from the shortlist and from meeting participants were selected for inclusion in the BOGP based on demonstration of PE Quality Criteria and willingness of initiative owners to collaborate.DiscussionThe PE Quality Guidance and BOGP are practical resources which will be continually updated in response to user feedback. They are not prescriptive, but rather based on core principles, which can be applied according to the unique needs of each interaction and initiative. Implementation of the guidance will facilitate improved and systematic PE across the medicines’ development lifecycle.
Study on the effects of raw materials composition and pelletization conditions on the quality and properties of pellets obtained from different woody and non woody biomasses.
The paper considers the issues of increasing the reliability of agricultural machinery through the use of reinforcing processing of recovered machine parts by plastic deformation, which provides an increase in the quality of their surface layer during recovery.
The operational stability of the piston fingers and the upper heads of the connecting rods restored by vibration reinforcement on the engines working in the mechanized agricultural complex was carried out: tractor - agricultural machine - car. Studies have shown that the amount of wear of piston fingers restored by the vibration deformation method is 1.23 times smaller than the traditional method of recovery, which confirms the effectiveness of vibration technology.
Technological processes of restoration of discs of diggers of beet harvesters, discs of coulters of grain planers, plow blades with use of vibrating vibrations of the processing tool are developed and put into production.
The results of these developments showed an increase of 1.21 times the time of beet harvester harvesting with the diggers' wheels with the vibration-strengthened method; an increase in technical use factor of 1.07 times, compared to new 65G steel wheels.
To improve the reliability of the PLN-5-35, PLN-3-35 plows, the technology of restoration of working bodies - blades is developed and introduced into production, which provides for increase of their durability and durability.
The coefficient of technical use of the plow units with the blades restored by the developed technology is 1.01 times higher than that of the plow units with the new blades made of 65G steel.
The wear rate of the toe, width and thickness of the blade are 1.51 respectively; 1.22 and 1.27 times less than the new 65G steel blades.
The results of the study of vibrating reinforcing processing of working bodies of agricultural machinery help to increase their resource, which provides increased reliability of machines.
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